1j48: Difference between revisions

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==Crystal Structure of Apo-C1027==
==Crystal Structure of Apo-C1027==
<StructureSection load='1j48' size='340' side='right' caption='[[1j48]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1j48' size='340' side='right'caption='[[1j48]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1j48]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_globisporus"_krasil'nikov_1941 "actinomyces globisporus" krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J48 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1j48]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J48 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j48 OCA], [http://pdbe.org/1j48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j48 RCSB], [http://www.ebi.ac.uk/pdbsum/1j48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1j48 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j48 OCA], [https://pdbe.org/1j48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j48 RCSB], [https://www.ebi.ac.uk/pdbsum/1j48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j48 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CAGA_STRGL CAGA_STRGL]] Binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.  
[https://www.uniprot.org/uniprot/CAGA_STRGL CAGA_STRGL] Binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/1j48_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/1j48_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Actinomyces globisporus krasil'nikov 1941]]
[[Category: Large Structures]]
[[Category: Bartlam, M]]
[[Category: Streptomyces globisporus]]
[[Category: Chen, Y]]
[[Category: Bartlam M]]
[[Category: Gao, Y]]
[[Category: Chen Y]]
[[Category: Jin, L]]
[[Category: Gao Y]]
[[Category: Li, J]]
[[Category: Jin L]]
[[Category: Liu, Y]]
[[Category: Li J]]
[[Category: Rao, Z]]
[[Category: Liu Y]]
[[Category: Shao, Y]]
[[Category: Rao Z]]
[[Category: Tang, H]]
[[Category: Shao Y]]
[[Category: Zhen, Y]]
[[Category: Tang H]]
[[Category: Antibiotic]]
[[Category: Zhen Y]]
[[Category: Dna-binding]]

Latest revision as of 02:42, 28 December 2023

Crystal Structure of Apo-C1027Crystal Structure of Apo-C1027

Structural highlights

1j48 is a 2 chain structure with sequence from Streptomyces globisporus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAGA_STRGL Binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1j48, resolution 1.80Å

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OCA
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