6elm: Difference between revisions

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New page: '''Unreleased structure''' The entry 6elm is ON HOLD Authors: Pinkas, D.M., Bufton, J.C., Newman, J.A., Chalk, R., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., B...
 
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'''Unreleased structure'''


The entry 6elm is ON HOLD
==Crystal structure of the human WNK2 CCT1 domain==
 
<StructureSection load='6elm' size='340' side='right'caption='[[6elm]], [[Resolution|resolution]] 1.14&Aring;' scene=''>
Authors: Pinkas, D.M., Bufton, J.C., Newman, J.A., Chalk, R., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6elm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ELM FirstGlance]. <br>
Description: Crystal structure of the human WNK2 CCT1 domain
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WNK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6elm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elm OCA], [http://pdbe.org/6elm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6elm RCSB], [http://www.ebi.ac.uk/pdbsum/6elm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6elm ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/WNK2_HUMAN WNK2_HUMAN]] Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.<ref>PMID:17667937</ref> <ref>PMID:18593598</ref> <ref>PMID:21733846</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bufton, J C]]
[[Category: Bullock, A]]
[[Category: Bullock, A]]
[[Category: Arrowsmith, C.H]]
[[Category: Burgess-Brown, N A]]
[[Category: Chalk, R]]
[[Category: Chalk, R]]
[[Category: Burgess-Brown, N.A]]
[[Category: Delft, F von]]
[[Category: Von Delft, F]]
[[Category: Edwards, A M]]
[[Category: Bufton, J.C]]
[[Category: Newman, J A]]
[[Category: Pinkas, D.M]]
[[Category: Pinkas, D M]]
[[Category: Edwards, A.M]]
[[Category: Ai domain]]
[[Category: Newman, J.A]]
[[Category: Cct domain]]
[[Category: Bountra, C]]
[[Category: Rfxv motif binding]]
[[Category: Structural genomic]]
[[Category: Wnk2]]

Latest revision as of 10:07, 16 October 2019

Crystal structure of the human WNK2 CCT1 domainCrystal structure of the human WNK2 CCT1 domain

Structural highlights

6elm is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:WNK2 (HUMAN)
Activity:Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[WNK2_HUMAN] Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.[1] [2] [3]

References

  1. ↑ Moniz S, Verissimo F, Matos P, Brazao R, Silva E, Kotelevets L, Chastre E, Gespach C, Jordan P. Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Oncogene. 2007 Sep 6;26(41):6071-81. doi: 10.1038/sj.onc.1210706. Epub 2007 Jul, 30. PMID:17667937 doi:http://dx.doi.org/10.1038/sj.onc.1210706
  2. ↑ Moniz S, Matos P, Jordan P. WNK2 modulates MEK1 activity through the Rho GTPase pathway. Cell Signal. 2008 Oct;20(10):1762-8. doi: 10.1016/j.cellsig.2008.06.002. Epub, 2008 Jun 14. PMID:18593598 doi:http://dx.doi.org/10.1016/j.cellsig.2008.06.002
  3. ↑ Rinehart J, Vazquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J Biol Chem. 2011 Aug 26;286(34):30171-80. doi: 10.1074/jbc.M111.222893. Epub, 2011 Jul 6. PMID:21733846 doi:http://dx.doi.org/10.1074/jbc.M111.222893

6elm, resolution 1.14Å

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