5ya2: Difference between revisions
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New page: '''Unreleased structure''' The entry 5ya2 is ON HOLD until Paper Publication Authors: Ryu, K.S., Ha, J.H. Description: Crystal structure of LsrK-HPr complex with ADP [[Category: Unrele... |
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==Crystal structure of LsrK-HPr complex with ADP== | |||
<StructureSection load='5ya2' size='340' side='right'caption='[[5ya2]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ya2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YA2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.701Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ya2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ya2 OCA], [https://pdbe.org/5ya2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ya2 RCSB], [https://www.ebi.ac.uk/pdbsum/5ya2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ya2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LSRK_ECOLI LSRK_ECOLI] Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. Required for the regulation of the lsr operon and many other genes.<ref>PMID:15601708</ref> <ref>PMID:17557827</ref> <ref>PMID:20025244</ref> | |||
==See Also== | |||
*[[Phosphocarrier protein HPr 3D structures|Phosphocarrier protein HPr 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Ha | __TOC__ | ||
[[Category: Ryu | </StructureSection> | ||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Ha JH]] | |||
[[Category: Ryu KS]] | |||
Latest revision as of 13:22, 27 March 2024
Crystal structure of LsrK-HPr complex with ADPCrystal structure of LsrK-HPr complex with ADP
Structural highlights
FunctionLSRK_ECOLI Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. Required for the regulation of the lsr operon and many other genes.[1] [2] [3] See AlsoReferences
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