5ohj: Difference between revisions

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'''Unreleased structure'''


The entry 5ohj is ON HOLD  until Paper Publication
==Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor.==
<StructureSection load='5ohj' size='340' side='right'caption='[[5ohj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ohj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OHJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9VE:[(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-1-ium-4-yl]-1-[4-[bis(fluoranyl)methoxy]-3-(cyclopropylmethoxy)phenyl]ethyl]+(2~{S})-1-[3-(dimethylcarbamoyl)phenyl]sulfonylpyrrolidine-2-carboxylate'>9VE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ohj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ohj OCA], [https://pdbe.org/5ohj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ohj RCSB], [https://www.ebi.ac.uk/pdbsum/5ohj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ohj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>


Authors: Rizzi, A., Carzaniga, L., Armani, E.
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
Description: Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor.
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Armani, E]]
__TOC__
[[Category: Carzaniga, L]]
</StructureSection>
[[Category: Rizzi, A]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Armani E]]
[[Category: Carzaniga L]]
[[Category: Rizzi A]]

Latest revision as of 10:27, 1 May 2024

Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor.Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor.

Structural highlights

5ohj is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE4B_HUMAN Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.[1] [2]

See Also

References

  1. ↑ Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT. Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity. Science. 2000 Jun 9;288(5472):1822-5. PMID:10846163
  2. ↑ Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT. Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J Mol Biol. 2004 Mar 19;337(2):355-65. PMID:15003452 doi:http://dx.doi.org/10.1016/j.jmb.2004.01.040

5ohj, resolution 1.60Å

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