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==Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8==
==Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8==
<StructureSection load='5do7' size='340' side='right' caption='[[5do7]], [[Resolution|resolution]] 3.93&Aring;' scene=''>
<StructureSection load='5do7' size='340' side='right'caption='[[5do7]], [[Resolution|resolution]] 3.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5do7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DO7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5do7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DO7 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5do7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do7 OCA], [http://pdbe.org/5do7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5do7 RCSB], [http://www.ebi.ac.uk/pdbsum/5do7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5do7 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.93&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5do7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do7 OCA], [https://pdbe.org/5do7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5do7 RCSB], [https://www.ebi.ac.uk/pdbsum/5do7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5do7 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ABCG5_HUMAN ABCG5_HUMAN]] Sitosterolemia. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/ABCG8_HUMAN ABCG8_HUMAN]] Sitosterolemia. Disease susceptibility may be associated with variations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/ABCG5_HUMAN ABCG5_HUMAN] Sitosterolemia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ABCG5_HUMAN ABCG5_HUMAN]] Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. [[http://www.uniprot.org/uniprot/ABCG8_HUMAN ABCG8_HUMAN]] Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
[https://www.uniprot.org/uniprot/ABCG5_HUMAN ABCG5_HUMAN] Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols in liver and intestines. Mutations disrupting G5G8 cause sitosterolaemia, a disorder characterized by sterol accumulation and premature atherosclerosis. Here we use crystallization in lipid bilayers to determine the X-ray structure of human G5G8 in a nucleotide-free state at 3.9 A resolution, generating the first atomic model of an ABC sterol transporter. The structure reveals a new transmembrane fold that is present in a large and functionally diverse superfamily of ABC transporters. The transmembrane domains are coupled to the nucleotide-binding sites by networks of interactions that differ between the active and inactive ATPases, reflecting the catalytic asymmetry of the transporter. The G5G8 structure provides a mechanistic framework for understanding sterol transport and the disruptive effects of mutations causing sitosterolaemia.


Crystal structure of the human sterol transporter ABCG5/ABCG8.,Lee JY, Kinch LN, Borek DM, Wang J, Wang J, Urbatsch IL, Xie XS, Grishin NV, Cohen JC, Otwinowski Z, Hobbs HH, Rosenbaum DM Nature. 2016 May 4;533(7604):561-4. doi: 10.1038/nature17666. PMID:27144356<ref>PMID:27144356</ref>
==See Also==
 
*[[ABC transporter 3D structures|ABC transporter 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5do7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Borek, D M]]
[[Category: Homo sapiens]]
[[Category: Cohen, J C]]
[[Category: Large Structures]]
[[Category: Grishin, N V]]
[[Category: Borek DM]]
[[Category: Hobbs, H H]]
[[Category: Cohen JC]]
[[Category: Kinch, L N]]
[[Category: Grishin NV]]
[[Category: Lee, J Y]]
[[Category: Hobbs HH]]
[[Category: Otwinowski, Z]]
[[Category: Kinch LN]]
[[Category: Rosenbaum, D M]]
[[Category: Lee J-Y]]
[[Category: Urbatsch, I L]]
[[Category: Otwinowski Z]]
[[Category: Xie, X S]]
[[Category: Rosenbaum DM]]
[[Category: Abcg]]
[[Category: Urbatsch IL]]
[[Category: Atp-binding cassette transporter]]
[[Category: Xie X-S]]
[[Category: Sitosterolemia]]
[[Category: Sterol efflux]]
[[Category: Transport protein]]

Latest revision as of 15:25, 6 March 2024

Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8

Structural highlights

5do7 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.93Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

ABCG5_HUMAN Sitosterolemia. The disease is caused by mutations affecting the gene represented in this entry.

Function

ABCG5_HUMAN Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

See Also

5do7, resolution 3.93Å

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