4unr: Difference between revisions
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==Mtb TMK in complex with compound 23== | ==Mtb TMK in complex with compound 23== | ||
<StructureSection load='4unr' size='340' side='right' caption='[[4unr]], [[Resolution|resolution]] 1.98Å' scene=''> | <StructureSection load='4unr' size='340' side='right'caption='[[4unr]], [[Resolution|resolution]] 1.98Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4unr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNR OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4unr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UNR FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QZE:4-[3-CYANO-2-OXO-7-(1H-PYRAZOL-4-YL)-5,6-DIHYDRO-1H-BENZO[H]QUINOLIN-4-YL]BENZOIC+ACID'>QZE</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QZE:4-[3-CYANO-2-OXO-7-(1H-PYRAZOL-4-YL)-5,6-DIHYDRO-1H-BENZO[H]QUINOLIN-4-YL]BENZOIC+ACID'>QZE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4unr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unr OCA], [https://pdbe.org/4unr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4unr RCSB], [https://www.ebi.ac.uk/pdbsum/4unr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4unr ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KTHY_MYCTU KTHY_MYCTU] Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth. Has a broad specificity for nucleoside triphosphates, being highly active with ATP or dATP as phosphate donors, and less active with ITP, GTP, CTP and UTP.[HAMAP-Rule:MF_00165] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Thymidylate kinase|Thymidylate kinase]] | *[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Gingell | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Hussein | [[Category: Gingell H]] | ||
[[Category: Read | [[Category: Hussein S]] | ||
[[Category: Tucker | [[Category: Read JA]] | ||
[[Category: Tucker J]] | |||