5gg8: Difference between revisions

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 ==Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-dGTP, 8-oxo-dGMP and pyrophosphate (II)==
-<StructureSection load='5gg8' size='340' side='right' caption='[[5gg8]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
+<StructureSection load='5gg8' size='340' side='right'caption='[[5gg8]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5gg8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GG8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5gg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GG8 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8DG:8-OXO-2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>8DG</scene>, <scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gg5|5gg5]], [[5gg6|5gg6]], [[5gg7|5gg7]], [[5gg9|5gg9]], [[5gga|5gga]], [[5ggb|5ggb]], [[5ggc|5ggc]], [[5ggd|5ggd]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8DG:8-OXO-2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>8DG</scene>, <scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gg8 OCA], [http://pdbe.org/5gg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gg8 RCSB], [http://www.ebi.ac.uk/pdbsum/5gg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gg8 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gg8 OCA], [https://pdbe.org/5gg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gg8 RCSB], [https://www.ebi.ac.uk/pdbsum/5gg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gg8 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/MUTT1_MYCS2 MUTT1_MYCS2] Catalyzes the conversion of 8-oxo-dGTP to 8-oxo-dGDP, and 8-oxo-GTP to 8-oxo-GDP (PubMed:16585780, PubMed:28375146). At high enzyme concentrations, can also catalyze the conversion of 8-oxo-dGDP to 8-oxo-dGMP, and 8-oxo-GDP to 8-oxo-GMP (PubMed:28375146). In addition, catalyzes the hydrolysis of the diadenosine polyphosphates diadenosine hexaphosphate (Ap6A), diadenosine pentaphosphate (Ap5A) and diadenosine tetraphosphate (Ap4A) (PubMed:28705712).<ref>PMID:16585780</ref> <ref>PMID:28375146</ref> <ref>PMID:28705712</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 19: @@
 </div>
 <div class="pdbe-citations 5gg8" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Arif, S M]]
+[[Category: Large Structures]]
-[[Category: Patil, A G]]
+[[Category: Mycolicibacterium smegmatis MC2 155]]
-[[Category: Varshney, U]]
+[[Category: Arif SM]]
-[[Category: Vijayan, M]]
+[[Category: Patil AG]]
-[[Category: 8-oxo-guanine nucleotide]]
+[[Category: Varshney U]]
-[[Category: Binding sites at intermolecular interface]]
+[[Category: Vijayan M]]
-[[Category: Enzyme action]]
-[[Category: Histidine phosphatase domain]]
-[[Category: Hydrolase]]
-[[Category: Nudix enzyme]]
-[[Category: Sanitization of nucleotide pool]]