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[[Image:1uld.gif|left|200px]]


{{Structure
==CGL2 in complex with blood group H type II==
|PDB= 1uld |SIZE=350|CAPTION= <scene name='initialview01'>1uld</scene>, resolution 2.10&Aring;
<StructureSection load='1uld' size='340' side='right'caption='[[1uld]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
<table><tr><td colspan='2'>[[1uld]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ULD FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 Coprinopsis cinerea])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900036:H+type+2+antigen,+beta+anomer'>PRD_900036</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uld OCA], [https://pdbe.org/1uld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uld RCSB], [https://www.ebi.ac.uk/pdbsum/1uld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uld ProSAT]</span></td></tr>
|RELATEDENTRY=[[1sla|1SLA]], [[1qmj|1QMJ]], [[1gan|1GAN]], [[1c1f|1C1F]], [[1bkz|1BKZ]], [[1a3k|1A3K]], [[1lcl|1LCL]], [[1is5|1IS5]], [[1ul9|1UL9]], [[1ulc|1ULC]], [[1ule|1ULE]], [[1ulf|1ULF]], [[1ulg|1ULG]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uld OCA], [http://www.ebi.ac.uk/pdbsum/1uld PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uld RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CGL2_COPCI CGL2_COPCI] Binds lactose. May play a role in fruiting body formation.<ref>PMID:8999822</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ul/1uld_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uld ConSurf].
<div style="clear:both"></div>


'''CGL2 in complex with blood group H type II'''
==See Also==
 
*[[Galectin 3D structures|Galectin 3D structures]]
 
== References ==
==Overview==
<references/>
Recognition of and discrimination between potential glyco-substrates is central to the function of galectins. Here we dissect the fundamental parameters responsible for such selectivity by the fungal representative, CGL2. The 2.1 A crystal structure of CGL2 and five substrate complexes reveal that this prototype galectin achieves increased substrate specificity by accommodating substituted oligosaccharides of the mammalian blood group A/B type in an extended binding cleft. Kinetic studies on wild-type and mutant CGL2 proteins demonstrate that the tetrameric organization is essential for functionality. The geometric constraints due to the orthogonal orientation of the four binding sites have important consequences on substrate binding and selectivity.
__TOC__
 
</StructureSection>
==About this Structure==
1ULD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULD OCA].
 
==Reference==
Structure and functional analysis of the fungal galectin CGL2., Walser PJ, Haebel PW, Kunzler M, Sargent D, Kues U, Aebi M, Ban N, Structure. 2004 Apr;12(4):689-702. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15062091 15062091]
[[Category: Coprinopsis cinerea]]
[[Category: Coprinopsis cinerea]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Aebi, M.]]
[[Category: Aebi M]]
[[Category: Ban, N.]]
[[Category: Ban N]]
[[Category: Haebel, P W.]]
[[Category: Haebel PW]]
[[Category: Kuenzler, M.]]
[[Category: Kuenzler M]]
[[Category: Kues, U.]]
[[Category: Kues U]]
[[Category: Walser, P J.]]
[[Category: Walser PJ]]
[[Category: beta-galactoside binding lectin]]
[[Category: galectin]]
[[Category: lectin]]
[[Category: sugar binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:11:49 2008''

Latest revision as of 09:16, 3 April 2024

CGL2 in complex with blood group H type IICGL2 in complex with blood group H type II

Structural highlights

1uld is a 4 chain structure with sequence from Coprinopsis cinerea. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CGL2_COPCI Binds lactose. May play a role in fruiting body formation.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Cooper DN, Boulianne RP, Charlton S, Farrell EM, Sucher A, Lu BC. Fungal galectins, sequence and specificity of two isolectins from Coprinus cinereus. J Biol Chem. 1997 Jan 17;272(3):1514-21. PMID:8999822

1uld, resolution 2.10Å

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