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==PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 103)==
==PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 103)==
<StructureSection load='5prw' size='340' side='right' caption='[[5prw]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='5prw' size='340' side='right'caption='[[5prw]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5prw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PRW FirstGlance]. <br>
<table><tr><td colspan='2'>[[5prw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PRW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5prw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5prw OCA], [http://pdbe.org/5prw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5prw RCSB], [http://www.ebi.ac.uk/pdbsum/5prw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5prw ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5prw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5prw OCA], [https://pdbe.org/5prw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5prw RCSB], [https://www.ebi.ac.uk/pdbsum/5prw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5prw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>
[https://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>  
 
==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Homo sapiens]]
[[Category: Bountra, C]]
[[Category: Large Structures]]
[[Category: Bradley, A R]]
[[Category: Arrowsmith CH]]
[[Category: Brandao-Neto, J]]
[[Category: Bountra C]]
[[Category: Brennan, P E]]
[[Category: Bradley AR]]
[[Category: Collins, P]]
[[Category: Brandao-Neto J]]
[[Category: Cox, O]]
[[Category: Brennan PE]]
[[Category: Delft, F von]]
[[Category: Collins P]]
[[Category: Dias, A]]
[[Category: Cox O]]
[[Category: Douangamath, A]]
[[Category: Dias A]]
[[Category: Edwards, A]]
[[Category: Douangamath A]]
[[Category: Fairhead, M]]
[[Category: Edwards A]]
[[Category: Krojer, T]]
[[Category: Fairhead M]]
[[Category: MacLean, E]]
[[Category: Krojer T]]
[[Category: Ng, J]]
[[Category: MacLean E]]
[[Category: Pearce, N M]]
[[Category: Ng J]]
[[Category: Renjie, Z]]
[[Category: Pearce NM]]
[[Category: Sethi, R]]
[[Category: Renjie Z]]
[[Category: Talon, R]]
[[Category: Sethi R]]
[[Category: Wright, N]]
[[Category: Talon R]]
[[Category: Bromodomain]]
[[Category: Wright N]]
[[Category: Epigenetic]]
[[Category: Von Delft F]]
[[Category: Gene regulation]]
[[Category: Pandda]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Xchemexplorer]]

Latest revision as of 16:14, 6 March 2024

PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 103)PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 103)

Structural highlights

5prw is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.65Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BRD1_HUMAN Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.[1] [2]

See Also

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Qin S, Jin L, Zhang J, Liu L, Ji P, Wu M, Wu J, Shi Y. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem. 2011 Oct 21;286(42):36944-55. doi: 10.1074/jbc.M111.244400. Epub, 2011 Aug 31. PMID:21880731 doi:http://dx.doi.org/10.1074/jbc.M111.244400

5prw, resolution 1.65Å

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