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[[Image:1tu1.jpg|left|200px]]


{{Structure
==Crystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative Regulator==
|PDB= 1tu1 |SIZE=350|CAPTION= <scene name='initialview01'>1tu1</scene>, resolution 1.95&Aring;
<StructureSection load='1tu1' size='340' side='right'caption='[[1tu1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[1tu1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TU1 FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
|GENE= PA0094 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5435 COG5435]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tu1 OCA], [https://pdbe.org/1tu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tu1 RCSB], [https://www.ebi.ac.uk/pdbsum/1tu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tu1 ProSAT], [https://www.topsan.org/Proteins/MCSG/1tu1 TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tu1 OCA], [http://www.ebi.ac.uk/pdbsum/1tu1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tu1 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/EAGT6_PSEAE EAGT6_PSEAE] Plays an essential role in toxin Tse6 delivery to target cells and specifically in the loading of Tse6 onto VgrG1a.<ref>PMID:30177742</ref>
 
== Evolutionary Conservation ==
'''Crystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative Regulator'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tu1_consurf.spt"</scriptWhenChecked>
1TU1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TU1 OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Pseudomonas aeruginosa]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Single protein]]
  </jmolCheckbox>
[[Category: Cymborowski, M.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tu1 ConSurf].
[[Category: Edwards, A.]]
<div style="clear:both"></div>
[[Category: Evdokimova, E.]]
== References ==
[[Category: Joachimiak, A.]]
<references/>
[[Category: MCSG, Midwest Center for Structural Genomics.]]
__TOC__
[[Category: Minor, W.]]
</StructureSection>
[[Category: Osipiuk, J.]]
[[Category: Large Structures]]
[[Category: Savchenko, A.]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: hypothetical protein]]
[[Category: Cymborowski M]]
[[Category: mcsg]]
[[Category: Edwards A]]
[[Category: midwest center for structural genomic]]
[[Category: Evdokimova E]]
[[Category: pa0094]]
[[Category: Joachimiak A]]
[[Category: protein structure initiative]]
[[Category: Minor W]]
[[Category: psi]]
[[Category: Osipiuk J]]
[[Category: structural genomic]]
[[Category: Savchenko A]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:01:06 2008''

Latest revision as of 11:42, 14 February 2024

Crystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative RegulatorCrystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative Regulator

Structural highlights

1tu1 is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

EAGT6_PSEAE Plays an essential role in toxin Tse6 delivery to target cells and specifically in the loading of Tse6 onto VgrG1a.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Quentin D, Ahmad S, Shanthamoorthy P, Mougous JD, Whitney JC, Raunser S. Mechanism of loading and translocation of type VI secretion system effector Tse6. Nat Microbiol. 2018 Sep 3. pii: 10.1038/s41564-018-0238-z. doi:, 10.1038/s41564-018-0238-z. PMID:30177742 doi:http://dx.doi.org/10.1038/s41564-018-0238-z

1tu1, resolution 1.95Å

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