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==Crystal structure of Human beta1-coronavirus OC43 NL/A/2005 Hemagglutinin-Esterase==
==Crystal structure of Human beta1-coronavirus OC43 NL/A/2005 Hemagglutinin-Esterase==
<StructureSection load='5n11' size='340' side='right' caption='[[5n11]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='5n11' size='340' side='right'caption='[[5n11]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5n11]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N11 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5n11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_OC43 Human coronavirus OC43]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N11 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sialate_O-acetylesterase Sialate O-acetylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.53 3.1.1.53] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n11 OCA], [http://pdbe.org/5n11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n11 RCSB], [http://www.ebi.ac.uk/pdbsum/5n11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n11 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n11 OCA], [https://pdbe.org/5n11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n11 RCSB], [https://www.ebi.ac.uk/pdbsum/5n11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n11 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q4VID6_CVHOC Q4VID6_CVHOC]] May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture.[RuleBase:RU361278]  
[https://www.uniprot.org/uniprot/Q4VID6_CVHOC Q4VID6_CVHOC] May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture.[RuleBase:RU361278]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5n11" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5n11" style="background-color:#fffaf0;"></div>
==See Also==
*[[Hemagglutinin-esterase 3D structures|Hemagglutinin-esterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Sialate O-acetylesterase]]
[[Category: Human coronavirus OC43]]
[[Category: Bakkers, M J.G]]
[[Category: Large Structures]]
[[Category: Feitsma, L J]]
[[Category: Bakkers MJG]]
[[Category: Groot, R J.de]]
[[Category: Feitsma LJ]]
[[Category: Huizinga, E G]]
[[Category: Huizinga EG]]
[[Category: Coronavirus]]
[[Category: De Groot RJ]]
[[Category: Esterase]]
[[Category: Hemagglutin]]
[[Category: Hepatitis virus]]
[[Category: Sialic acid]]
[[Category: Viral protein]]

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