5ls6: Difference between revisions

<StructureSection load='5ls6' size='340' side='right'caption='[[5ls6]], [[Resolution|resolution]] 3.47&Aring;' scene=''>

<table><tr><td colspan='2'>[[5ls6]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LS6 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.47&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=74D:1-[(1~{R})-1-[1-[2,2-BIS(FLUORANYL)PROPYL]PIPERIDIN-4-YL]ETHYL]-~{N}-[(4-METHOXY-6-METHYL-2-OXIDANYLIDENE-3~{H}-PYRIDIN-3-YL)METHYL]-2-METHYL-INDOLE-3-CARBOXAMIDE'>74D</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ls6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ls6 OCA], [https://pdbe.org/5ls6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ls6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ls6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ls6 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN] Weaver syndrome. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN] Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA.<ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16179254</ref> <ref>PMID:16618801</ref> <ref>PMID:16357870</ref> <ref>PMID:16936726</ref> <ref>PMID:17210787</ref> <ref>PMID:17344414</ref> <ref>PMID:19026781</ref> <ref>PMID:18285464</ref> <ref>PMID:20935635</ref> <ref>PMID:23063525</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chen S]]

[[Category: Gamblin S]]

[[Category: Justin N]]

[[Category: Wilson J]]

[[Category: Zhang Y]]