3wpc: Difference between revisions

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 ==Crystal structure of horse TLR9 in complex with agonistic DNA1668_12mer==
-<StructureSection load='3wpc' size='340' side='right' caption='[[3wpc]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+<StructureSection load='3wpc' size='340' side='right'caption='[[3wpc]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3wpc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WPC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3wpc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WPC FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wpb|3wpb]], [[3wpd|3wpd]], [[3wpe|3wpe]], [[3wpf|3wpf]], [[3wpg|3wpg]], [[3wph|3wph]], [[3wpi|3wpi]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpc OCA], [http://pdbe.org/3wpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wpc RCSB], [http://www.ebi.ac.uk/pdbsum/3wpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wpc ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpc OCA], [https://pdbe.org/3wpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wpc RCSB], [https://www.ebi.ac.uk/pdbsum/3wpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wpc ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/TLR9_HORSE TLR9_HORSE] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).[UniProtKB:Q9NR96]<ref>PMID:25686612</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 21: @@
 ==See Also==
-*[[Toll-like Receptors|Toll-like Receptors]]
+*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ohto, U]]
+[[Category: Equus caballus]]
-[[Category: Shimizu, T]]
+[[Category: Large Structures]]
-[[Category: Tanji, H]]
+[[Category: Synthetic construct]]
-[[Category: Dna binding]]
+[[Category: Ohto U]]
-[[Category: Dna binding protein-dna complex]]
+[[Category: Shimizu T]]
-[[Category: Glycosylation]]
+[[Category: Tanji H]]
-[[Category: Innate immunity]]
-[[Category: Leucine rich repeat]]
-[[Category: Receptor]]