4r3h: Difference between revisions

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==The crystal structure of an apo RNA binding protein==
==The crystal structure of an apo RNA binding protein==
<StructureSection load='4r3h' size='340' side='right' caption='[[4r3h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4r3h' size='340' side='right'caption='[[4r3h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4r3h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3H FirstGlance]. <br>
<table><tr><td colspan='2'>[[4r3h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r3i|4r3i]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3h OCA], [http://pdbe.org/4r3h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r3h RCSB], [http://www.ebi.ac.uk/pdbsum/4r3h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3h OCA], [https://pdbe.org/4r3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3h RCSB], [https://www.ebi.ac.uk/pdbsum/4r3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/YTDC1_HUMAN YTDC1_HUMAN]] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:20167602</ref> 
[https://www.uniprot.org/uniprot/YTDC1_HUMAN YTDC1_HUMAN] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:20167602</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
N6-methyladenosine (m6A) is the most abundant internal modification of nearly all eukaryotic mRNAs and has recently been reported to be recognized by the YTH domain family proteins. Here we present the crystal structures of the YTH domain of YTHDC1, a member of the YTH domain family, and its complex with an m6A-containing RNA. Our structural studies, together with transcriptome-wide identification of YTHDC1-binding sites and biochemical experiments, not only reveal the specific mode of m6A-YTH binding but also explain the preferential recognition of the GG(m6A)C sequences by YTHDC1.
 
Structural basis for selective binding of mA RNA by the YTHDC1 YTH domain.,Xu C, Wang X, Liu K, Roundtree IA, Tempel W, Li Y, Lu Z, He C, Min J Nat Chem Biol. 2014 Sep 21. doi: 10.1038/nchembio.1654. PMID:25242552<ref>PMID:25242552</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4r3h" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Homo sapiens]]
[[Category: Bountra, C]]
[[Category: Large Structures]]
[[Category: Edwards, A M]]
[[Category: Arrowsmith CH]]
[[Category: Li, Y]]
[[Category: Bountra C]]
[[Category: Liu, K]]
[[Category: Edwards AM]]
[[Category: Min, J]]
[[Category: Li Y]]
[[Category: Structural genomic]]
[[Category: Liu K]]
[[Category: Tempel, W]]
[[Category: Min J]]
[[Category: Xu, C]]
[[Category: Tempel W]]
[[Category: Rna binding protein]]
[[Category: Xu C]]
[[Category: Sgc]]

Latest revision as of 15:50, 1 March 2024

The crystal structure of an apo RNA binding proteinThe crystal structure of an apo RNA binding protein

Structural highlights

4r3h is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

YTDC1_HUMAN RNA-binding protein that regulates alternative splice site selection.[1]

References

  1. ↑ Zhang Z, Theler D, Kaminska KH, Hiller M, de la Grange P, Pudimat R, Rafalska I, Heinrich B, Bujnicki JM, Allain FH, Stamm S. The YTH domain is a novel RNA binding domain. J Biol Chem. 2010 May 7;285(19):14701-10. doi: 10.1074/jbc.M110.104711. Epub 2010, Feb 18. PMID:20167602 doi:http://dx.doi.org/10.1074/jbc.M110.104711

4r3h, resolution 1.90Å

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