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==Caspase-7 S239E Phosphomimetic==
==Caspase-7 S239E Phosphomimetic==
<StructureSection load='5k20' size='340' side='right' caption='[[5k20]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5k20' size='340' side='right'caption='[[5k20]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5k20]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K20 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5k20]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K20 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ibf|3ibf]], [[3s8e|3s8e]], [[1k86|1k86]], [[3r5k|3r5k]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k20 OCA], [https://pdbe.org/5k20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k20 RCSB], [https://www.ebi.ac.uk/pdbsum/5k20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k20 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k20 OCA], [http://pdbe.org/5k20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k20 RCSB], [http://www.ebi.ac.uk/pdbsum/5k20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k20 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.  
[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
 
==See Also==
*[[Caspase 3D structures|Caspase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Caspase-7]]
[[Category: Homo sapiens]]
[[Category: Eron, S J]]
[[Category: Large Structures]]
[[Category: Hardy, J A]]
[[Category: Eron SJ]]
[[Category: Hydrolase]]
[[Category: Hardy JA]]
[[Category: Pak2]]
[[Category: Phosphomimetic]]
[[Category: Phosphorylation]]
[[Category: Protease]]

Latest revision as of 22:18, 20 September 2023

Caspase-7 S239E PhosphomimeticCaspase-7 S239E Phosphomimetic

Structural highlights

5k20 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CASP7_HUMAN Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

See Also

5k20, resolution 2.20Å

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