Keratins: Difference between revisions
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Both microfilaments and microtubules are assembled from globular subunits of actin and tubulin respectively. In contrast, intermediate filaments (IFs) are composed of proteins that have a long fibrous structure that results from long stretches of alpha helical domains. | Both microfilaments and microtubules are assembled from globular subunits of actin and tubulin respectively. In contrast, intermediate filaments (IFs) are composed of proteins that have a long fibrous structure that results from long stretches of alpha helical domains. | ||
The basic building block of each intermediate filament is a dimer of a coiled-coil pair of IF proteins. Each keratin filament is assembled as a hetero-dimer of a type I keratin coiled together with a type II keratin. <ref name="Hanukoglu-1983">PMID:6191871</ref>. Other types of IFs are mostly composed of homo-dimers <ref name="Godsel-2008" />. | The basic building block of each intermediate filament is a dimer of a coiled-coil pair of IF proteins (see [[Coiled coil]]). Each keratin filament is assembled as a hetero-dimer of a type I keratin coiled together with a type II keratin. <ref name="Hanukoglu-1983">PMID:6191871</ref>. Other types of IFs are mostly composed of homo-dimers <ref name="Godsel-2008" />. | ||
==Primary structures of keratins== | ==Primary structures of keratins== | ||
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==Bonds that hold the coiled-coil structure== | ==Bonds that hold the coiled-coil structure== | ||
<Structure load='3TNU' size=' | <Structure load='3TNU' size='400' frame='' align='right' caption='Fig. 2. Crystal structure of the 2B helical domain of coiled-coil dimer of type I keratin K14 (chain A) and type II keratin K5 (chain B) (residues Ser332-Gly421 of K14 and Thr382-Gly476 of K5). PDB ID: 3tnu. | ||
Please click the green colored links in the text in order to view highlighted features of the structure.' /> | Please click the green colored links in the text in order to view highlighted features of the structure.' /> | ||
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==3D structure of keratin== | ==3D structure of keratin== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[3tnu]] - hKRT14 residues 295-422 + hKRT5 residues 350-477 - | [[4zry]], [[6e2j]], [[6uui]] – hKRT1 coil 2B domain + hKRT10 coil 2B domain – human<br /> | ||
[[6ec0]] – hKRT10 coil 1B domain + hKRT1 coil 1B domain <br /> | |||
[[6e2j]] – hKRT10 coil 1B domain + hKRT1 coil 1B domain (mutant)<br /> | |||
[[6ec0]] – hKRT1 coil 1B domain + hKRT10 coil 1B domain <br /> | |||
[[3tnu]] - hKRT14 residues 295-422 + hKRT5 residues 350-477 <br /> | |||
[[6jfv]] - hKRT14 residues 327-421 (mutant) + hKRT5 residues 379-476 <br /> | |||
[[3asw]], [[4f1z]] - hKRT10 peptide + clumping factor B<br /> | [[3asw]], [[4f1z]] - hKRT10 peptide + clumping factor B<br /> | ||