Z-DNA: Difference between revisions
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<StructureSection load='Z-DNA.pdb' size=' | <StructureSection load='Z-DNA.pdb' size='350' side='right' scene='Z-DNA/Z-dna_new/1' caption=''> | ||
'''Z-DNA''' <scene name='Z-DNA/Z-dna_new/1'>(default scene)</scene> is a form of DNA that has a different structure from the more common <scene name='Sandbox_Z-DNA/Bdna/3'>B-DNA</scene> form.It is a left-handed double helix wherein the sugar-phosphate backbone has a zigzag pattern due to the alternate stacking of bases in [http://proteopedia.org/wiki/index.php/Syn_and_anti_nucleosides anti-conformation and syn conformation]. In Z-DNA only a minor groove is present and the major groove is absent. The residues that allow sequence-specific recognition of Z-DNA are present on the convex outer surface.<ref name = 'Rich'> PMID:12838348</ref> This DNA form is thought to play a role in the regulation of gene expression, DNA processing events and/or genetic instability.<ref name = 'Wang'>PMID:17485386</ref> | '''Z-DNA''' <scene name='Z-DNA/Z-dna_new/1'>(default scene)</scene> is a form of DNA that has a different structure from the more common <scene name='Sandbox_Z-DNA/Bdna/3'>B-DNA</scene> form.It is a left-handed double helix wherein the sugar-phosphate backbone has a zigzag pattern due to the alternate stacking of bases in [http://proteopedia.org/wiki/index.php/Syn_and_anti_nucleosides anti-conformation and syn conformation]. In Z-DNA only a minor groove is present and the major groove is absent. The residues that allow sequence-specific recognition of Z-DNA are present on the convex outer surface.<ref name = 'Rich'> PMID:12838348</ref> This DNA form is thought to play a role in the regulation of gene expression, DNA processing events and/or genetic instability.<ref name = 'Wang'>PMID:17485386</ref> | ||
See also [[Z-DNA model tour]]. | See also [[Z-DNA model tour]] and [[B-DNA tour]]. | ||
== Structure == | == Structure == | ||
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__NOTOC__ | __NOTOC__ | ||
== Movie Depicting ADAR1 binding to Z-DNA == | == Movie Depicting ADAR1 binding to Z-DNA == | ||
< | <html5media height="315" width="560">http://www.youtube.com/embed/tvrWkld8TBY</html5media> | ||
== Comparison of the three helices and helical parameters of DNA == | == Comparison of the three helices and helical parameters of DNA == | ||
''Sources''<ref>http://203.129.231.23/indira/nacc/</ref> | ''Sources''<ref>http://203.129.231.23/indira/nacc/</ref> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1woe]], [[3qba]] – ZDNA hexamer CGCGCG<br /> | [[1woe]], [[3qba]], [[1i0t]], [[6aqt]], [[6aqv]], [[6aqw]], [[6aqx]], [[2ie1]], [[1da1]], [[1ick]], [[313d]], [[314d]], [[390d]], [[391d]], [[392d]], [[3p4j]], [[3qba]], [[3wbo]], [[400d]], [[4fs5]], [[4fs6]], [[4hif]], [[4hig]], [[2hto]], [[2htt]], [[4r15]], [[4xsn]], [[6bst]] – ZDNA hexamer CGCGCG<br /> | ||
[[1v9g]] – ZDNA hexamer CGCGCG - Neutron<br /> | |||
[[1tne]] – ZDNA hexamer CGCGCG - NMR<br /> | |||
[[2obz]] – ZDNA hexamer CGCGUG<br /> | |||
[[362d]] – ZDNA hexamer TGCGCA<br /> | |||
[[1qbj]] – ZDNA hexamer CGCGCG + hADAR1 Zα domain - human<br /> | [[1qbj]] – ZDNA hexamer CGCGCG + hADAR1 Zα domain - human<br /> | ||
[[2heo]] - ZDNA hexamer CGCGCG + Z-DNA-binding protein Zα domain – mouse<br /> | [[2heo]] - ZDNA hexamer CGCGCG + Z-DNA-binding protein Zα domain – mouse<br /> | ||
[[ | [[1sfu]] - ZDNA hexamer CGCGCG + Pox virus Z-DNA-binding protein Zα domain <br /> | ||
[[4wcg]] - ZDNA hexamer CGCGCG + Herpes virus 3 Z-DNA-binding protein Zα domain <br /> | |||
[[1j75]] - ZDNA hexamer CGCGCG + DLM-1 Z-DNA-binding protein Zα domain <br /> | |||
[[3f21]] - ZDNA hexamer CACGTG + double-stranded RNA-specific adenosine deaminase Z-DNA-binding protein Zα domain <br /> | |||
[[3f21]] - ZDNA hexamer CGTACG + double-stranded RNA-specific adenosine deaminase Z-DNA-binding protein Zα domain <br /> | |||
[[3eyi]] - ZDNA hexamer CGCGCG + Z-DNA-binding protein Zβ domain<br /> | |||
[[1j75]] - ZDNA hexamer CGCGCG + DLM-1 Zα domain<br /> | [[1j75]] - ZDNA hexamer CGCGCG + DLM-1 Zα domain<br /> | ||
[[3fqb]] - ZDNA hexamer CGCGTG + Ba<br /> | |||
==Additional Resources== | ==Additional Resources== | ||