4pu4: Difference between revisions

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 ==Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P21)==
-<StructureSection load='4pu4' size='340' side='right' caption='[[4pu4]], [[Resolution|resolution]] 3.79&Aring;' scene=''>
+<StructureSection load='4pu4' size='340' side='right'caption='[[4pu4]], [[Resolution|resolution]] 3.79&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4pu4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PU4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PU4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4pu4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_oneidensis Shewanella oneidensis] and [https://en.wikipedia.org/wiki/Shewanella_oneidensis_MR-1 Shewanella oneidensis MR-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PU4 FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.786&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pu3|4pu3]], [[4pu5|4pu5]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pu4 OCA], [http://pdbe.org/4pu4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pu4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pu4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pu4 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pu4 OCA], [https://pdbe.org/4pu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pu4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pu4 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/HIPA_SHEON HIPA_SHEON] Toxic component of a type II toxin-antitoxin (TA) system; overexpression in wild-type temporarily inhibits cell growth, overexpression in a hipAB deletion leads to acute growth inhibition. The toxic effect of HipA is neutralized by its cognate antitoxin HipB. In the ternary phosphoserine-HipA-HipB-DNA complex the DNA is bent about 125 degrees; all HipA in the crystallized ternary complex is phosphorylated. In E.coli phosphorylation of HipA is thought to release HipB from the HipA-HipB-DNA complex, suggesting the complex functions differently in the 2 bacteria (PubMed:25056321). Phosphorylates Glu-tRNA-ligase (GltX, on 'Ser-239') in vivo, with HipB probably acts as a corepressor for transcription of the hipBA promoter (By similarity).[UniProtKB:P23874]<ref>PMID:25056321</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 19: @@
 </div>
 <div class="pdbe-citations 4pu4" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Behiels, E]]
+[[Category: Large Structures]]
-[[Category: Devreese, B]]
+[[Category: Shewanella oneidensis]]
-[[Category: Elegheert, J]]
+[[Category: Shewanella oneidensis MR-1]]
-[[Category: Felix, J]]
+[[Category: Behiels E]]
-[[Category: Savvides, S]]
+[[Category: Devreese B]]
-[[Category: Vergauwen, B]]
+[[Category: Elegheert J]]
-[[Category: Wen, Y]]
+[[Category: Felix J]]
-[[Category: Toxin antitoxin system]]
+[[Category: Savvides S]]
-[[Category: Toxin-antitoxin-dna complex]]
+[[Category: Vergauwen B]]
+[[Category: Wen Y]]