5mr8: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 5mr8 is ON HOLD
+==Crystal structure of TRIM33 PHD-Bromodomain isoform B in complex with H3K9ac histone peptide==
+<StructureSection load='5mr8' size='340' side='right'caption='[[5mr8]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5mr8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MR8 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mr8 OCA], [https://pdbe.org/5mr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mr8 RCSB], [https://www.ebi.ac.uk/pdbsum/5mr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mr8 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/TRI33_HUMAN TRI33_HUMAN] Papillary or follicular thyroid carcinoma. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TRIM33 is found in thyroid papillary carcinomas. Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.
+== Function ==
+[https://www.uniprot.org/uniprot/TRI33_HUMAN TRI33_HUMAN] Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).<ref>PMID:10022127</ref> <ref>PMID:15820681</ref> <ref>PMID:16751102</ref> <ref>PMID:19135894</ref>
-Authors: Tallant, C., Savitsky, P., Fedorov, O., Nunez-Alonso, G., Siejka, P., Krojer, T., Williams, E., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S., Structural Genomics Consortium (SGC)
+==See Also==
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
-Description: Crystal structure of TRIM33 PHD-Bromodomain isoform B in complex with H3K9ac histone peptide
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Nunez-Alonso, G]]
+__TOC__
-[[Category: Fedorov, O]]
+</StructureSection>
-[[Category: Muller, S]]
+[[Category: Homo sapiens]]
-[[Category: Siejka, P]]
+[[Category: Large Structures]]
-[[Category: Knapp, S]]
+[[Category: Arrowsmith CH]]
-[[Category: Krojer, T]]
+[[Category: Bountra C]]
-[[Category: Bountra, C]]
+[[Category: Edwards AM]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Fedorov O]]
-[[Category: Williams, E]]
+[[Category: Knapp S]]
-[[Category: Von Delft, F]]
+[[Category: Krojer T]]
-[[Category: Edwards, A.M]]
+[[Category: Muller S]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Nunez-Alonso G]]
-[[Category: Tallant, C]]
+[[Category: Savitsky P]]
-[[Category: Srikannathasan, V]]
+[[Category: Siejka P]]
-[[Category: Savitsky, P]]
+[[Category: Srikannathasan V]]
+[[Category: Tallant C]]
+[[Category: Williams E]]
+[[Category: Von Delft F]]