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==Crystal structure of catalytic domain of human beta1,4galactosyltransferase 7 in closed conformation in complex with manganese and UDP==
==Crystal structure of catalytic domain of human beta1,4galactosyltransferase 7 in closed conformation in complex with manganese and UDP==
<StructureSection load='4irq' size='340' side='right' caption='[[4irq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4irq' size='340' side='right'caption='[[4irq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4irq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IRQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4irq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IRQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4irp|4irp]], [[3lw6|3lw6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">4galactosyltransferase, B4GALT7, beta1, UNQ748/PRO1478, XGALT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4irq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4irq OCA], [https://pdbe.org/4irq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4irq RCSB], [https://www.ebi.ac.uk/pdbsum/4irq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4irq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4irq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4irq OCA], [http://pdbe.org/4irq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4irq RCSB], [http://www.ebi.ac.uk/pdbsum/4irq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4irq ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/B4GT7_HUMAN B4GT7_HUMAN]] Ehlers-Danlos syndrome, progeroid type. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/B4GT7_HUMAN B4GT7_HUMAN] Ehlers-Danlos syndrome, progeroid type. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/B4GT7_HUMAN B4GT7_HUMAN]] Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.  
[https://www.uniprot.org/uniprot/B4GT7_HUMAN B4GT7_HUMAN] Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4irq" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4irq" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Qasba, P K]]
[[Category: Large Structures]]
[[Category: Ramakrishnan, B]]
[[Category: Qasba PK]]
[[Category: Tsutsui, Y]]
[[Category: Ramakrishnan B]]
[[Category: Closed conformation]]
[[Category: Tsutsui Y]]
[[Category: Glycosyltransferase]]
[[Category: Golgi]]
[[Category: Gt-a fold]]
[[Category: Manganese and udp complex]]
[[Category: Transferase]]

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