Survivin: Difference between revisions
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<StructureSection load='3uig' size='340' side='right' caption='Structure of human survivin dimer ( | <StructureSection load='3uig' size='340' side='right' caption='Structure of human survivin dimer (magenta and green) complex with histone H3 peptide (cyan) and Zn+2 ion (grey) (PDB code [[3uig]]).' scene='59/596423/Cv/2'> | ||
== Function == | == Function == | ||
'''Survivin''' or '''apoptosis inhibitor 4''' (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation<ref>PMID:9850056</ref>. Survivin is part of the chromosomal passanger complex (CPC) which includes also [[Borealin]] and [[INCENP]] <ref>PMID:23175282</ref>. | '''Survivin''' or '''apoptosis inhibitor 4''' or '''baculoviral IAP repeat-containing protein 5''' (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation<ref>PMID:9850056</ref>. Survivin is part of the chromosomal passanger complex (CPC) which includes also [[Borealin]] and [[INCENP]] <ref>PMID:23175282</ref>. | ||
== Disease == | == Disease == | ||
IAP4 is found in human cancer cells<ref>PMID:18032822</ref>. and can serve as a cancer marker and as a target for chemotherapy<ref>PMID:22680927</ref>. | IAP4 is found in human cancer cells<ref>PMID:18032822</ref>. and can serve as a cancer marker and as a target for chemotherapy<ref>PMID:22680927</ref>. | ||
*<scene name='59/596423/Cv/6'>Human survivin interactions with histone H3 peptide</scene> (PDB code [[3uig]]). | |||
*<scene name='59/596423/Cv/7'>Zn coordination site in the human survivin</scene> (PDB code [[3uig]]). | |||
</StructureSection> | </StructureSection> | ||
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*Survivin | *Survivin | ||
**[[1e31]] – hIAP4 – human<br /> | **[[1e31]], [[6sho]] – hIAP4 – human<br /> | ||
**[[1f3h]], [[3ueg]], [[3ueh]], [[3uei]] – hIAP4 (mutant) <br /> | **[[1f3h]], [[3ueg]], [[3ueh]], [[3uei]] – hIAP4 (mutant) <br /> | ||
**[[1xox]] – hIAP4 – NMR<br /> | **[[1xox]] – hIAP4 – NMR<br /> | ||
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**[[2raw]], [[2rax]] – hIAP4 + Borealin N-terminal<br /> | **[[2raw]], [[2rax]] – hIAP4 + Borealin N-terminal<br /> | ||
**[[2qfa]] – hIAP4 + Borealin N-terminal + inner centromere protein<br /> | **[[2qfa]], [[6yie]] – hIAP4 + Borealin N-terminal + inner centromere protein<br /> | ||
**[[6yif]], [[6yih]] – hIAP4 + Borealin N-terminal + inner centromere protein + histone H3 peptide<br /> | |||
**[[4a0i]] – hIAP4 + shugoshin peptide<br /> | **[[4a0i]] – hIAP4 + shugoshin peptide<br /> | ||
**[[4a0j]], [[4a0n]], [[3uig]], [[3uii]], [[3ued]] – hIAP4 + histone H3 peptide<br /> | **[[4a0j]], [[4a0n]], [[3uig]], [[3uii]], [[3ued]], [[7lbk]], [[7lbo]], [[7lbp]], [[7lbq]] – hIAP4 + histone H3 peptide<br /> | ||
**[[3uik]], [[3uec]], [[3uee]], [[3uef]] – hIAP4 (mutant) + histone H3 peptide<br /> | **[[3uik]], [[3uec]], [[3uee]], [[3uef]] – hIAP4 (mutant) + histone H3 peptide<br /> | ||
**[[3uih]] – hIAP4 + diablo peptide<br /> | **[[3uih]] – hIAP4 + diablo peptide<br /> | ||