Survivin: Difference between revisions
Jump to navigation
Jump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (8 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='3uig' size='340' side='right' caption='Structure of human survivin dimer ( | <StructureSection load='3uig' size='340' side='right' caption='Structure of human survivin dimer (magenta and green) complex with histone H3 peptide (cyan) and Zn+2 ion (grey) (PDB code [[3uig]]).' scene='59/596423/Cv/2'> | ||
== Function == | == Function == | ||
'''Survivin''' or '''apoptosis inhibitor 4''' (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation<ref>PMID:9850056</ref>. Survivin is part of the chromosomal passanger complex (CPC) which includes also | '''Survivin''' or '''apoptosis inhibitor 4''' or '''baculoviral IAP repeat-containing protein 5''' (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation<ref>PMID:9850056</ref>. Survivin is part of the chromosomal passanger complex (CPC) which includes also [[Borealin]] and [[INCENP]] <ref>PMID:23175282</ref>. | ||
== Disease == | == Disease == | ||
IAP4 is found in human cancer cells<ref>PMID:18032822</ref>. and can serve as a cancer marker and as a target for chemotherapy<ref>PMID:22680927</ref>. | IAP4 is found in human cancer cells<ref>PMID:18032822</ref>. and can serve as a cancer marker and as a target for chemotherapy<ref>PMID:22680927</ref>. | ||
*<scene name='59/596423/Cv/6'>Human survivin interactions with histone H3 peptide</scene> (PDB code [[3uig]]). | |||
*<scene name='59/596423/Cv/7'>Zn coordination site in the human survivin</scene> (PDB code [[3uig]]). | |||
</StructureSection> | </StructureSection> | ||
| Line 17: | Line 19: | ||
*Survivin | *Survivin | ||
**[[1e31]] – hIAP4 – human<br /> | **[[1e31]], [[6sho]] – hIAP4 – human<br /> | ||
**[[1f3h]], [[3ueg]], [[3ueh]], [[3uei]] – hIAP4 (mutant) <br /> | **[[1f3h]], [[3ueg]], [[3ueh]], [[3uei]] – hIAP4 (mutant) <br /> | ||
**[[1xox]] – hIAP4 – NMR<br /> | **[[1xox]] – hIAP4 – NMR<br /> | ||
| Line 25: | Line 27: | ||
**[[2raw]], [[2rax]] – hIAP4 + Borealin N-terminal<br /> | **[[2raw]], [[2rax]] – hIAP4 + Borealin N-terminal<br /> | ||
**[[2qfa]] – hIAP4 + Borealin N-terminal + inner centromere protein<br /> | **[[2qfa]], [[6yie]] – hIAP4 + Borealin N-terminal + inner centromere protein<br /> | ||
**[[6yif]], [[6yih]] – hIAP4 + Borealin N-terminal + inner centromere protein + histone H3 peptide<br /> | |||
**[[4a0i]] – hIAP4 + shugoshin peptide<br /> | **[[4a0i]] – hIAP4 + shugoshin peptide<br /> | ||
**[[4a0j]], [[4a0n]], [[3uig]], [[3uii]], [[3ued]] – hIAP4 + histone H3 peptide<br /> | **[[4a0j]], [[4a0n]], [[3uig]], [[3uii]], [[3ued]], [[7lbk]], [[7lbo]], [[7lbp]], [[7lbq]] – hIAP4 + histone H3 peptide<br /> | ||
**[[3uik]], [[3uec]], [[3uee]], [[3uef]] – hIAP4 (mutant) + histone H3 peptide<br /> | **[[3uik]], [[3uec]], [[3uee]], [[3uef]] – hIAP4 (mutant) + histone H3 peptide<br /> | ||
**[[3uih]] – hIAP4 + diablo peptide<br /> | **[[3uih]] – hIAP4 + diablo peptide<br /> | ||
Latest revision as of 10:29, 14 April 2022
FunctionSurvivin or apoptosis inhibitor 4 or baculoviral IAP repeat-containing protein 5 (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation[1]. Survivin is part of the chromosomal passanger complex (CPC) which includes also Borealin and INCENP [2]. DiseaseIAP4 is found in human cancer cells[3]. and can serve as a cancer marker and as a target for chemotherapy[4]. |
| ||||||||||
3D structures of survivin3D structures of survivin
Updated on 14-April-2022
ReferencesReferences
- ↑ Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20. PMID:9850056
- ↑ Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474. PMID:23175282 doi:http://dx.doi.org/10.1038/nrm3474
- ↑ Zaffaroni N, Costa A, Pennati M, De Marco C, Affini E, Madeo M, Erdas R, Cabras A, Kusamura S, Baratti D, Deraco M, Daidone MG. Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma. Cell Oncol. 2007;29(6):453-66. PMID:18032822
- ↑ Rodel F, Sprenger T, Kaina B, Liersch T, Rodel C, Fulda S, Hehlgans S. Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Curr Med Chem. 2012;19(22):3679-88. PMID:22680927