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==The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2== | ==The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2== | ||
<StructureSection load='5f8t' size='340' side='right' caption='[[5f8t]], [[Resolution|resolution]] 1.75Å' scene=''> | <StructureSection load='5f8t' size='340' side='right'caption='[[5f8t]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5f8t]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj5 4zj5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8T OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5f8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj5 4zj5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F8T FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8t OCA], [https://pdbe.org/5f8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f8t RCSB], [https://www.ebi.ac.uk/pdbsum/5f8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8t ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | ||
==See Also== | |||
*[[Kallikrein 3D structures|Kallikrein 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Andreasen P]] | ||
[[Category: | [[Category: Huang M]] | ||
[[Category: | [[Category: Jiang L]] | ||
[[Category: | [[Category: Luo Z]] | ||
[[Category: | [[Category: Xu M]] | ||
[[Category: | [[Category: Xu P]] | ||
Latest revision as of 09:42, 19 July 2023
The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
Structural highlights
DiseaseKLKB1_HUMAN Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. FunctionKLKB1_HUMAN The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. See Also |
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