1o9a: Difference between revisions

<StructureSection load='1o9a' size='340' side='right'caption='[[1o9a]]' scene=''>

<table><tr><td colspan='2'>[[1o9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_dysgalactiae Streptococcus dysgalactiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O9A FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o9a OCA], [https://pdbe.org/1o9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o9a RCSB], [https://www.ebi.ac.uk/pdbsum/1o9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o9a ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>  

[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>  Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o9/1o9a_consurf.spt"</scriptWhenChecked>

     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

*[[Fibronectin 3D structures|Fibronectin 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Streptococcus dysgalactiae]]

[[Category: Briggs JAG]]

[[Category: Campbell ID]]

[[Category: Gurusiddappa S]]

[[Category: Hook M]]

[[Category: Pickford AR]]

[[Category: Pilka ES]]

[[Category: Potts JR]]

[[Category: Schwarz-Linek U]]

[[Category: Werner JM]]