4az5: Difference between revisions

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==Differential inhibition of the tandem GH20 catalytic modules in the pneumococcal exo-beta-D-N-acetylglucosaminidase, StrH==
==Differential inhibition of the tandem GH20 catalytic modules in the pneumococcal exo-beta-D-N-acetylglucosaminidase, StrH==
<StructureSection load='4az5' size='340' side='right' caption='[[4az5]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
<StructureSection load='4az5' size='340' side='right'caption='[[4az5]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4az5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AZ5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4az5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AZ5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NGW:(2S,3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-METHYL-2,3A,5,6,7,7A-HEXAHYDRO-1H-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>NGW</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yl5|2yl5]], [[2yl6|2yl6]], [[2yl8|2yl8]], [[2yl9|2yl9]], [[2yla|2yla]], [[2yll|2yll]], [[4az6|4az6]], [[4az7|4az7]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NGW:(2S,3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-METHYL-2,3A,5,6,7,7A-HEXAHYDRO-1H-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>NGW</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4az5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4az5 OCA], [https://pdbe.org/4az5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4az5 RCSB], [https://www.ebi.ac.uk/pdbsum/4az5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4az5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4az5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4az5 OCA], [http://pdbe.org/4az5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4az5 RCSB], [http://www.ebi.ac.uk/pdbsum/4az5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4az5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STRH_STRPN STRH_STRPN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]]
*[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Beta-N-acetylhexosaminidase]]
[[Category: Large Structures]]
[[Category: Strpn]]
[[Category: Streptococcus pneumoniae TIGR4]]
[[Category: Boraston, A B]]
[[Category: Boraston AB]]
[[Category: Pluvinage, B]]
[[Category: Pluvinage B]]
[[Category: Stubbs, K A]]
[[Category: Stubbs KA]]
[[Category: Vocadlo, D J]]
[[Category: Vocadlo DJ]]
[[Category: Hydrolase]]

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