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==X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with cytidine and sulphate==
==X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with cytidine and sulphate==
<StructureSection load='5ey3' size='340' side='right' caption='[[5ey3]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
<StructureSection load='5ey3' size='340' side='right'caption='[[5ey3]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ey3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EY3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ey3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EY3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CTN:4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE'>CTN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.905&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xr5|4xr5]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CTN:4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE'>CTN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_phosphorylase Thymidine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ey3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ey3 OCA], [https://pdbe.org/5ey3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ey3 RCSB], [https://www.ebi.ac.uk/pdbsum/5ey3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ey3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ey3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ey3 OCA], [http://pdbe.org/5ey3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ey3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ey3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ey3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYPH_SALTY TYPH_SALTY]] The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.  
[https://www.uniprot.org/uniprot/TYPH_SALTY TYPH_SALTY] The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Thymidine phosphorylase]]
[[Category: Large Structures]]
[[Category: Balaev, V V]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Betzel, C]]
[[Category: Balaev VV]]
[[Category: Gabdulkhakov, A G]]
[[Category: Betzel C]]
[[Category: Lashkov, A A]]
[[Category: Gabdulkhakov AG]]
[[Category: Mikhailov, A M]]
[[Category: Lashkov AA]]
[[Category: Metabolism]]
[[Category: Mikhailov AM]]
[[Category: Nucleoside]]
[[Category: Transferase]]

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