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==the structure of mini-MFN1 apo==
==the structure of mini-MFN1 apo==
<StructureSection load='5gnu' size='340' side='right' caption='[[5gnu]], [[Resolution|resolution]] 4.11&Aring;' scene=''>
<StructureSection load='5gnu' size='340' side='right'caption='[[5gnu]], [[Resolution|resolution]] 4.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5gnu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GNU FirstGlance]. <br>
<table><tr><td colspan='2'>[[5gnu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GNU FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gnr|5gnr]], [[5gns|5gns]], [[5gnt|5gnt]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.113&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gnu OCA], [http://pdbe.org/5gnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gnu RCSB], [http://www.ebi.ac.uk/pdbsum/5gnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gnu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gnu OCA], [https://pdbe.org/5gnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gnu RCSB], [https://www.ebi.ac.uk/pdbsum/5gnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gnu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MFN1_HUMAN MFN1_HUMAN]] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:11181170</ref> <ref>PMID:12475957</ref> <ref>PMID:12759376</ref> <ref>PMID:23921378</ref>
[https://www.uniprot.org/uniprot/MFN1_HUMAN MFN1_HUMAN] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:11181170</ref> <ref>PMID:12475957</ref> <ref>PMID:12759376</ref> <ref>PMID:23921378</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lou, J]]
[[Category: Homo sapiens]]
[[Category: Lou, Z]]
[[Category: Large Structures]]
[[Category: Ming, Z]]
[[Category: Lou J]]
[[Category: Rao, Z]]
[[Category: Lou Z]]
[[Category: Yan, L]]
[[Category: Ming Z]]
[[Category: Yu, C]]
[[Category: Rao Z]]
[[Category: Hydrolase]]
[[Category: Yan L]]
[[Category: Mfn1]]
[[Category: Yu C]]
[[Category: Mitochondria fusion]]

Latest revision as of 14:37, 2 August 2023

the structure of mini-MFN1 apothe structure of mini-MFN1 apo

Structural highlights

5gnu is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 4.113Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MFN1_HUMAN Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.[1] [2] [3] [4]

References

  1. ↑ Santel A, Fuller MT. Control of mitochondrial morphology by a human mitofusin. J Cell Sci. 2001 Mar;114(Pt 5):867-74. PMID:11181170
  2. ↑ Legros F, Lombes A, Frachon P, Rojo M. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell. 2002 Dec;13(12):4343-54. PMID:12475957 doi:http://dx.doi.org/10.1091/mbc.E02-06-0330
  3. ↑ Santel A, Frank S, Gaume B, Herrler M, Youle RJ, Fuller MT. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J Cell Sci. 2003 Jul 1;116(Pt 13):2763-74. Epub 2003 May 20. PMID:12759376 doi:http://dx.doi.org/10.1242/jcs.00479
  4. ↑ Palmer CS, Elgass KD, Parton RG, Osellame LD, Stojanovski D, Ryan MT. Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J Biol Chem. 2013 Sep 20;288(38):27584-93. doi: 10.1074/jbc.M113.479873. Epub, 2013 Aug 6. PMID:23921378 doi:http://dx.doi.org/10.1074/jbc.M113.479873

5gnu, resolution 4.11Å

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