3mx5: Difference between revisions
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==Lassa fever virus nucleoprotein complexed with UTP== | ==Lassa fever virus nucleoprotein complexed with UTP== | ||
<StructureSection load='3mx5' size='340' side='right' caption='[[3mx5]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='3mx5' size='340' side='right'caption='[[3mx5]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3mx5]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3mx5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MX5 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.903Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mx5 OCA], [https://pdbe.org/3mx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mx5 RCSB], [https://www.ebi.ac.uk/pdbsum/3mx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mx5 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Nucleoprotein|Nucleoprotein]] | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Dong | [[Category: Lassa virus Josiah]] | ||
[[Category: Dong | [[Category: Dong C]] | ||
[[Category: Lan | [[Category: Dong H]] | ||
[[Category: Liang | [[Category: Lan S]] | ||
[[Category: Ly | [[Category: Liang Y]] | ||
[[Category: Qi | [[Category: Ly H]] | ||
[[Category: Qi X]] | |||
[[Category: Schelde | [[Category: Schelde LM]] | ||
[[Category: Wallat | [[Category: Wallat G]] | ||
[[Category: Wang | [[Category: Wang W]] | ||