5tn2: Difference between revisions

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'''Unreleased structure'''


The entry 5tn2 is ON HOLD  until Paper Publication
==Solution Structure of the C-terminal multimerization domain of the master biofilm-regulator SinR from Bacillus subtilis==
 
<StructureSection load='5tn2' size='340' side='right'caption='[[5tn2]]' scene=''>
Authors: Draughn, G.L., Bobay, B.G., Stowe, S.D., Thompson, R.J., Cavanagh, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5tn2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TN2 FirstGlance]. <br>
Description: Solution Structure of the C-terminal multimerization domain of the master biofilm-regulator SinR from Bacillus subtilis
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tn2 OCA], [https://pdbe.org/5tn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tn2 RCSB], [https://www.ebi.ac.uk/pdbsum/5tn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tn2 ProSAT]</span></td></tr>
[[Category: Bobay, B.G]]
</table>
[[Category: Thompson, R.J]]
== Function ==
[[Category: Cavanagh, J]]
[https://www.uniprot.org/uniprot/SINR_BACSU SINR_BACSU] Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.<ref>PMID:1898931</ref> <ref>PMID:7642487</ref> <ref>PMID:15661000</ref> <ref>PMID:16923912</ref>
[[Category: Stowe, S.D]]
== References ==
[[Category: Draughn, G.L]]
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Large Structures]]
[[Category: Bobay BG]]
[[Category: Cavanagh J]]
[[Category: Draughn GL]]
[[Category: Stowe SD]]
[[Category: Thompson RJ]]

Latest revision as of 18:42, 6 March 2024

Solution Structure of the C-terminal multimerization domain of the master biofilm-regulator SinR from Bacillus subtilisSolution Structure of the C-terminal multimerization domain of the master biofilm-regulator SinR from Bacillus subtilis

Structural highlights

5tn2 is a 4 chain structure with sequence from Bacillus subtilis subsp. subtilis str. 168. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SINR_BACSU Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemble into multicellular communities. Acts with Hpr as a corepressor of epr expression. Also negatively regulates transcription of the lutABC operon, which is required for lactate utilization. Repressor activity is regulated by SinI.[1] [2] [3] [4]

References

  1. ↑ Gaur NK, Oppenheim J, Smith I. The Bacillus subtilis sin gene, a regulator of alternate developmental processes, codes for a DNA-binding protein. J Bacteriol. 1991 Jan;173(2):678-86. PMID:1898931
  2. ↑ Mandic-Mulec I, Doukhan L, Smith I. The Bacillus subtilis SinR protein is a repressor of the key sporulation gene spo0A. J Bacteriol. 1995 Aug;177(16):4619-27. PMID:7642487
  3. ↑ Kearns DB, Chu F, Branda SS, Kolter R, Losick R. A master regulator for biofilm formation by Bacillus subtilis. Mol Microbiol. 2005 Feb;55(3):739-49. PMID:15661000 doi:10.1111/j.1365-2958.2004.04440.x
  4. ↑ Kodgire P, Dixit M, Rao KK. ScoC and SinR negatively regulate epr by corepression in Bacillus subtilis. J Bacteriol. 2006 Sep;188(17):6425-8. PMID:16923912 doi:10.1128/JB.00427-06
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