Uridine 5'-monophosphate synthase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='2v30' size='340' side='right' caption='Human uridine 5-monophosphate synthase OPD subunit dimer complex with UMP (stick model), [[2v30]]' scene='' >
+<StructureSection load='' size='350' side='right' caption='Human uridine 5-monophosphate synthase OPD subunit dimer complex with UMP [[2qcd]]' scene='52/526172/Cv/1' pspeed='8'>
 == Function ==
-'''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP)<ref>PMID:8631878</ref>.  UMPS N-terminal domain is an '''orotate phosphoribosyl transferase''' (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP).  The C-terminal subunit is '''orotidine 5’-phosphate decarboxylase''' (OPD) which decarboxylates OMP to form UMP.
+'''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme which catalyzes the formation of uridine monophosphate (UMP)<ref>PMID:8631878</ref>.  UMPS '''N-terminal domain''' is an '''orotate phosphoribosyltransferase''' (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP).  The '''C-terminal subunit''' is '''orotidine 5’-phosphate decarboxylase''' (OPD) or '''OMP decarboxylase''' which decarboxylates OMP to form UMP. Potent inhibitors of OPD are BMP – a barbituric acid derivative and xanthosine-5'-monophosphate (XMP).
 == Disease ==
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 == Structural highlights ==
+<scene name='52/526172/Cv/8'>UMPS contains UMP</scene> in its <scene name='52/526172/Cv/9'>nucleotide-binding pocket</scene><ref>PMID:18184586</ref> (the surface of chain B doesn't shown). Water molecules are shown as red spheres.
+==3D structures of uridine 5'-monophosphate synthase==
+[[Uridine 5'-monophosphate synthase 3D structures]]
 </StructureSection>
-==3D structures of uridine 5'-monophosphate synthase==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Uridine 5’-monophosphate synthase OPD subunit
-**[[3gdk]] - yOPD – yeast<br />
-**[[1dqw]], [[3gdr]], [[3gdm]] – yOPD (mutant) <br />
-**[[2eaw]], [[2jgy]], [[2p1f]], [[2qcc]], [[2qce]] - hOPD – human
-*Uridine 5’-monophosphate synthase OPD subunit complex
-**[[2v30]], [[2qcd]] - hOPD + UMP<br />
-**[[3ewy]] - hOPD (mutant) + UMP<br />
-**[[3gdl]] - yOPD + UMP derivative<br />
-**[[1dqx]], [[3gdt]] - yOPD (mutant) + UMP derivative<br />
-**[[2qcg]], [[2qch]], [[3bgg]], [[3bgj]], [[3bk0]], [[3g3d]], [[3g3m]], [[3ewz]], [[3ex2]], [[3ex3]], [[3ex4]], [[3dbp]], [[3l0k]], [[3l0n]], [[3mo7]], [[3mw7]] - hOPD + UMP derivative<br />
-**[[3bvj]] - hOPD + xanthosine 5’-monophosphate<br />
-**[[2qcf]], [[2qcm]], [[2qcn]], [[3ewu]], [[3ewx]], [[3ex6]] - hOPD (mutant) + UMP derivative<br />
-**[[3mi2]], [[4hib]], [[4hkp]] - hOPD + inhibitor<br />
-**[[3ex1]] - hOPD + UMP derivative + UMP<br />
-**[[2qcl]] - yOPD (mutant) + OMP
-*Uridine 5’-monophosphate synthase OPRT subunit complex
-**[[2wns]] - hOPRT + OMP
-}}
 ==References==
 <references />
 [[Category:Topic Page]]