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==Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3==
==Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3==
<StructureSection load='5k22' size='340' side='right' caption='[[5k22]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5k22' size='340' side='right'caption='[[5k22]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5k22]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K22 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5k22]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K22 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5k23|5k23]], [[5k24|5k24]], [[5k25|5k25]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k22 OCA], [https://pdbe.org/5k22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k22 RCSB], [https://www.ebi.ac.uk/pdbsum/5k22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k22 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k22 OCA], [http://pdbe.org/5k22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k22 RCSB], [http://www.ebi.ac.uk/pdbsum/5k22 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k22 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TP4A2_HUMAN TP4A2_HUMAN]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.<ref>PMID:14643450</ref>  [[http://www.uniprot.org/uniprot/CNNM3_HUMAN CNNM3_HUMAN]] Probable metal transporter.  
[https://www.uniprot.org/uniprot/CNNM3_HUMAN CNNM3_HUMAN] Probable metal transporter.
== References ==
 
<references/>
==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Homo sapiens]]
[[Category: Gehring, K]]
[[Category: Large Structures]]
[[Category: Kozlov, G]]
[[Category: Gehring K]]
[[Category: Wu, H]]
[[Category: Kozlov G]]
[[Category: Alpha-beta fold]]
[[Category: Wu H]]
[[Category: Complex]]
[[Category: Phosphatase]]
[[Category: Protein binding]]
[[Category: Transport protein-protein binding complex]]

Latest revision as of 15:38, 6 March 2024

Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3

Structural highlights

5k22 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CNNM3_HUMAN Probable metal transporter.

See Also

5k22, resolution 3.00Å

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