5tf9: Difference between revisions

<StructureSection load='5tf9' size='340' side='right'caption='[[5tf9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[5tf9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TF9 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7AV:{2-[(4-CHLOROPHENYL)METHOXY]PHENYL}{5-[2-(METHYLAMINO)-1,3-THIAZOL-4-YL]-2,3-DIHYDRO-1H-INDOL-1-YL}METHANONE'>7AV</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tf9 OCA], [https://pdbe.org/5tf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tf9 RCSB], [https://www.ebi.ac.uk/pdbsum/5tf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tf9 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/WNK1_HUMAN WNK1_HUMAN] Hereditary sensory and autonomic neuropathy type 2;Pseudohypoaldosteronism type 2C. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/WNK1_HUMAN WNK1_HUMAN] Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.<ref>PMID:10660600</ref> <ref>PMID:15060842</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Gunawan J]]

[[Category: Xie X]]