5eho: Difference between revisions

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'''Unreleased structure'''


The entry 5eho is ON HOLD  until Paper Publication
==Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach==
<StructureSection load='5eho' size='340' side='right'caption='[[5eho]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5eho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EHO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5O1:~{N}8-CYCLOHEXYL-~{N}2-[2-METHOXY-4-(1-METHYLPYRAZOL-4-YL)PHENYL]PYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE'>5O1</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eho OCA], [https://pdbe.org/5eho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eho RCSB], [https://www.ebi.ac.uk/pdbsum/5eho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eho ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>


Authors: Innocenti, P., Woodward, H.L., Solanki, S., Naud, N., Westwood, I.M., Cronin, N., Hayes, A., Roberts, J., Henley, A.T., Baker, R., Faisal, A., Mak, G., Box, G., Valenti, M., De Haven Brandon, A., O'Fee, L., Saville, J., Schmitt, J., Burke, R., van Montfort, R.L.M., Raymaud, F.I., Eccles, S.A., Linardopoulos, S., Blagg, J., Hoelder, S.
==See Also==
 
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
Description: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Burke, R]]
__TOC__
[[Category: Van Montfort, R.L.M]]
</StructureSection>
[[Category: Woodward, H.L]]
[[Category: Homo sapiens]]
[[Category: Hoelder, S]]
[[Category: Large Structures]]
[[Category: Solanki, S]]
[[Category: Baker R]]
[[Category: Innocenti, P]]
[[Category: Blagg J]]
[[Category: Hayes, A]]
[[Category: Box G]]
[[Category: Blagg, J]]
[[Category: Burke R]]
[[Category: Westwood, I.M]]
[[Category: Cronin N]]
[[Category: Valenti, M]]
[[Category: De Haven Brandon A]]
[[Category: Mak, G]]
[[Category: Eccles SA]]
[[Category: Henley, A.T]]
[[Category: Faisal A]]
[[Category: Cronin, N]]
[[Category: Hayes A]]
[[Category: Raymaud, F.I]]
[[Category: Henley AT]]
[[Category: Saville, J]]
[[Category: Hoelder S]]
[[Category: De Haven Brandon, A]]
[[Category: Innocenti P]]
[[Category: Eccles, S.A]]
[[Category: Linardopoulos S]]
[[Category: Box, G]]
[[Category: Mak G]]
[[Category: Linardopoulos, S]]
[[Category: Naud N]]
[[Category: Schmitt, J]]
[[Category: O'Fee L]]
[[Category: O'Fee, L]]
[[Category: Raymaud FI]]
[[Category: Faisal, A]]
[[Category: Roberts J]]
[[Category: Baker, R]]
[[Category: Saville J]]
[[Category: Roberts, J]]
[[Category: Schmitt J]]
[[Category: Naud, N]]
[[Category: Solanki S]]
[[Category: Valenti M]]
[[Category: Westwood IM]]
[[Category: Woodward HL]]
[[Category: Van Montfort RLM]]

Latest revision as of 09:28, 5 July 2023

Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization ApproachRapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach

Structural highlights

5eho is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.18Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TTK_HUMAN Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]

See Also

References

  1. ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046

5eho, resolution 2.18Å

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