5tdh: Difference between revisions

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New page: '''Unreleased structure''' The entry 5tdh is ON HOLD Authors: Liu, P., Jai, M.-Z., Zhou, X.E., de Waal, P.W., Dickson, B.M., Liu, B., Hou, L., Yin, Y.-T., Kang, Y.-Y., Shi, Y., Melcher,...
 
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'''Unreleased structure'''


The entry 5tdh is ON HOLD
==The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S==
<StructureSection load='5tdh' size='340' side='right'caption='[[5tdh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5tdh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TDH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tdh OCA], [https://pdbe.org/5tdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tdh RCSB], [https://www.ebi.ac.uk/pdbsum/5tdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tdh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>


Authors: Liu, P., Jai, M.-Z., Zhou, X.E., de Waal, P.W., Dickson, B.M., Liu, B., Hou, L., Yin, Y.-T., Kang, Y.-Y., Shi, Y., Melcher, K., Xu, H.E., Jiang, Y.
==See Also==
 
*[[Transducin 3D structures|Transducin 3D structures]]
Description: The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Zhou, X.E]]
__TOC__
[[Category: Xu, H.E]]
</StructureSection>
[[Category: Melcher, K]]
[[Category: Bos taurus]]
[[Category: Kang, Y.-Y]]
[[Category: Homo sapiens]]
[[Category: Jiang, Y]]
[[Category: Large Structures]]
[[Category: Liu, P]]
[[Category: Rattus norvegicus]]
[[Category: Dickson, B.M]]
[[Category: Dickson BM]]
[[Category: Jai, M.-Z]]
[[Category: Hou L]]
[[Category: Yin, Y.-T]]
[[Category: Jia M-Z]]
[[Category: Shi, Y]]
[[Category: Jiang Y]]
[[Category: Hou, L]]
[[Category: Kang Y-Y]]
[[Category: Liu, B]]
[[Category: Liu B]]
[[Category: De Waal, P.W]]
[[Category: Liu P]]
[[Category: Melcher K]]
[[Category: Shi Y]]
[[Category: Xu HE]]
[[Category: Yin Y-T]]
[[Category: Zhou XE]]
[[Category: De Waal PW]]

Latest revision as of 18:40, 6 March 2024

The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326SThe crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S

Structural highlights

5tdh is a 6 chain structure with sequence from Bos taurus, Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GNAI1_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.[1] [2]

See Also

References

  1. ↑ Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114
  2. ↑ Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

5tdh, resolution 3.00Å

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