5t30: Difference between revisions

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-'''Unreleased structure'''
-The entry 5t30 is ON HOLD  until Paper Publication
+==Human MnSOD-azide complex==
+<StructureSection load='5t30' size='340' side='right'caption='[[5t30]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5t30]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T30 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t30 OCA], [https://pdbe.org/5t30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t30 RCSB], [https://www.ebi.ac.uk/pdbsum/5t30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t30 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN] Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:[https://omim.org/entry/612634 612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
+== Function ==
+[https://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.<ref>PMID:10334867</ref>
-Authors: Azadmanesh, J., Trickel, S.R., Kolar, C.H., Lovelace, J.J., Borgstahl, G.E.O.
+==See Also==
+*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
-Description: Human MnSOD-azide complex
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Azadmanesh, J]]
+__TOC__
-[[Category: Trickel, S.R]]
+</StructureSection>
-[[Category: Lovelace, J.J]]
+[[Category: Homo sapiens]]
-[[Category: Kolar, C.H]]
+[[Category: Large Structures]]
-[[Category: Borgstahl, G.E.O]]
+[[Category: Azadmanesh J]]
+[[Category: Borgstahl GEO]]
+[[Category: Kolar CH]]
+[[Category: Lovelace JJ]]
+[[Category: Trickel SR]]