5tb6: Difference between revisions

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-'''Unreleased structure'''
-The entry 5tb6 is ON HOLD
+==Structure of bromodomain of CREBBP with a pyrazolo[4,3-c]pyridin fragment==
+<StructureSection load='5tb6' size='340' side='right'caption='[[5tb6]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5tb6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TB6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=77X:1-(3-PHENYL-1,4,6,7-TETRAHYDROPYRAZOLO[4,3-C]PYRIDIN-5-YL)PROPAN-1-ONE'>77X</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tb6 OCA], [https://pdbe.org/5tb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tb6 RCSB], [https://www.ebi.ac.uk/pdbsum/5tb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tb6 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.  Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
-Authors: Filippakopoulos, P., Picaud, S., Knapp, S., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Structural Genomics Consortium (SGC)
+==See Also==
+*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
-Description: Structure of romodomain of CREBBO with a pyrazolo[4,3-c]pyridin fragment
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Picaud, S]]
+__TOC__
-[[Category: Knapp, S]]
+</StructureSection>
-[[Category: Bountra, C]]
+[[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Large Structures]]
-[[Category: Von Delft, F]]
+[[Category: Arrowsmith CH]]
-[[Category: Filippakopoulos, P]]
+[[Category: Bountra C]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Edwards A]]
-[[Category: Edwards, A]]
+[[Category: Filippakopoulos P]]
+[[Category: Knapp S]]
+[[Category: Picaud S]]
+[[Category: Von Delft F]]