5t8l: Difference between revisions
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==Crystal structure of Snf7 under 350 MPa== | |||
<StructureSection load='5t8l' size='340' side='right'caption='[[5t8l]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5t8l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T8L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t8l OCA], [https://pdbe.org/5t8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t8l RCSB], [https://www.ebi.ac.uk/pdbsum/5t8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t8l ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Huang | == Function == | ||
[https://www.uniprot.org/uniprot/SNF7_YEAST SNF7_YEAST] Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Appears to sequester MVB cargo. Recruits BRO1, which in turn recruits DOA4, which deubiquitinates cargos before their enclosure within MVB vesicles.<ref>PMID:11559748</ref> <ref>PMID:12194857</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Huang Q]] | |||
[[Category: Szebenyi D]] | |||
Latest revision as of 15:56, 4 October 2023
Crystal structure of Snf7 under 350 MPaCrystal structure of Snf7 under 350 MPa
Structural highlights
FunctionSNF7_YEAST Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Appears to sequester MVB cargo. Recruits BRO1, which in turn recruits DOA4, which deubiquitinates cargos before their enclosure within MVB vesicles.[1] [2] References
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