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==Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae==
==Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae==
<StructureSection load='4z2d' size='340' side='right' caption='[[4z2d]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
<StructureSection load='4z2d' size='340' side='right'caption='[[4z2d]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>
<table><tr><td colspan='2'>[[4z2d]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z2D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.38&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4koe|4koe]], [[4pxp|4pxp]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[3ksb|3ksb]], [[3ksa|3ksa]], [[4i3h|4i3h]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFX:(3S)-9-FLUORO-3-METHYL-10-(4-METHYLPIPERAZIN-1-YL)-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC+ACID'>LFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [https://pdbe.org/4z2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [https://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2d OCA], [http://pdbe.org/4z2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2d RCSB], [http://www.ebi.ac.uk/pdbsum/4z2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q9R867_STREE Q9R867_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] [[http://www.uniprot.org/uniprot/Q59957_STREE Q59957_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]  
[https://www.uniprot.org/uniprot/GYRA_STRR6 GYRA_STRR6] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897]
 
==See Also==
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Crevel, I M.T]]
[[Category: Escherichia coli]]
[[Category: Fisher, L M]]
[[Category: Large Structures]]
[[Category: Laponogov, I]]
[[Category: Streptococcus pneumoniae]]
[[Category: Pan, X S]]
[[Category: Crevel IM-T]]
[[Category: Sanderson, M R]]
[[Category: Fisher LM]]
[[Category: Selvarajah, J]]
[[Category: Laponogov I]]
[[Category: Veselkov, D A]]
[[Category: Pan X-S]]
[[Category: Cleavage complex]]
[[Category: Sanderson MR]]
[[Category: Dna]]
[[Category: Selvarajah J]]
[[Category: Gyrase]]
[[Category: Veselkov DA]]
[[Category: Isomerase]]
[[Category: Quinolone]]

Latest revision as of 13:57, 10 January 2024

Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniaeQuinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae

Structural highlights

4z2d is a 8 chain structure with sequence from Escherichia coli and Streptococcus pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.38Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GYRA_STRR6 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897]

See Also

4z2d, resolution 3.38Å

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