5t89: Difference between revisions

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-'''Unreleased structure'''
-The entry 5t89 is ON HOLD
+==Crystal structure of VEGF-A in complex with VEGFR-1 domains D1-6==
+<StructureSection load='5t89' size='340' side='right'caption='[[5t89]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5t89]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T89 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t89 OCA], [https://pdbe.org/5t89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t89 RCSB], [https://www.ebi.ac.uk/pdbsum/5t89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t89 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN] Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:[https://omim.org/entry/603933 603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
+== Function ==
+[https://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN] Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.<ref>PMID:11427521</ref> <ref>PMID:15520188</ref> <ref>PMID:16489009</ref>
-Authors: Markovic-Mueller, S., Stuttfeld, E., Asthana, M., Weinert, T., Bliven, S., Goldie, K.N., Kisko, K., Capitani, G., Ballmer-Hofer, K.
+==See Also==
+*[[3D structures of vascular endothelial growth factor receptor|3D structures of vascular endothelial growth factor receptor]]
-Description: Crystal structure of VEGF-A in complex with VEGFR-1 domains D1-6
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Asthana, M]]
+__TOC__
-[[Category: Goldie, K.N]]
+</StructureSection>
-[[Category: Stuttfeld, E]]
+[[Category: Homo sapiens]]
-[[Category: Ballmer-Hofer, K]]
+[[Category: Large Structures]]
-[[Category: Kisko, K]]
+[[Category: Asthana M]]
-[[Category: Bliven, S]]
+[[Category: Ballmer-Hofer K]]
-[[Category: Capitani, G]]
+[[Category: Bliven S]]
-[[Category: Weinert, T]]
+[[Category: Capitani G]]
-[[Category: Markovic-Mueller, S]]
+[[Category: Goldie KN]]
+[[Category: Kisko K]]
+[[Category: Markovic-Mueller S]]
+[[Category: Stuttfeld E]]
+[[Category: Weinert T]]