Tissue factor: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' caption='Structure of human tissue factor (green) complex with coagulation factor VIIa heavy chain (magenta) and light chain (deep sky blue) and Ca+2 ion (green) (PDB code [[1j9c]]).' scene='59/595166/Cv/1'> | ||
== Function == | == Function == | ||
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== Relevance == | == Relevance == | ||
TF expression by cardiac myocytes is important to maintain heart hemostasis under normal and pathologic conditions<ref>PMID:17663739</ref>. | TF expression by cardiac myocytes is important to maintain heart hemostasis under normal and pathologic conditions<ref>PMID:17663739</ref>. | ||
*<scene name='59/595166/Cv/3'>Human tissue factor complex with coagulation factor VIIa heavy chain, light chain and Ca+2 ion</scene> (PDB code [[1j9c]]). | |||
</StructureSection> | </StructureSection> | ||
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*Tissue factor | *Tissue factor | ||
**[[2hft]], [[1boy]], [[1tfh]] – hTF extracellular domain – human<br /> | |||
**[[1a21]] – rTF extracellular domain – rabbit<br /> | **[[1a21]] – rTF extracellular domain – rabbit<br /> | ||
*Tissue factor binary complex | *Tissue factor binary complex | ||
**[[1dan]], [[1j9c]], [[1w0y]], [[4ylq]], [[4z6a]], [[4zma]] – hTF extracellular domain + factor VIIA<br /> | **[[1dan]], [[1j9c]], [[1w0y]], [[4ylq]], [[4z6a]], [[4zma]], [[6r2w]] – hTF extracellular domain + factor VIIA<br /> | ||
**[[1o5d]] – hTF extracellular domain (mutant) + factor VIIA<br /> | **[[1o5d]] – hTF extracellular domain (mutant) + factor VIIA<br /> | ||
**[[1ahw]], [[1jps]], [[1uj3]], [[4m7l]] – hTF extracellular domain + antibody<br /> | **[[1ahw]], [[1jps]], [[1uj3]], [[4m7l]], [[5w06]] – hTF extracellular domain + antibody<br /> | ||
*Tissue factor ternary complex with coagulation factor VIIa and inhibitor | *Tissue factor ternary complex with coagulation factor VIIa and inhibitor | ||