5t14: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 5t14 is ON HOLD
+==DNA polymerase kappa extending beyond a bulky major benzo[a]pyrene adduct==
+<StructureSection load='5t14' size='340' side='right'caption='[[5t14]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5t14]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T14 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DZ4:2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]ADENOSINE'>DZ4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=VKJ:2-DEOXY-N-[(7R,8S,9R,10S)-7,8,9-TRIHYDROXY-7,8,9,10-TETRAHYDROBENZO[PQR]TETRAPHEN-10-YL]GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>VKJ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t14 OCA], [https://pdbe.org/5t14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t14 RCSB], [https://www.ebi.ac.uk/pdbsum/5t14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t14 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/POLK_HUMAN POLK_HUMAN] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.<ref>PMID:10620008</ref> <ref>PMID:11024016</ref> <ref>PMID:12145297</ref> <ref>PMID:12444249</ref> <ref>PMID:12952891</ref> <ref>PMID:14630940</ref> <ref>PMID:15533436</ref>
-Authors: Jha, V.K., Ling, H.
+==See Also==
+*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
-Description: DNA polymerase kappa extending beyond a bulky major benzo[a]pyrene adduct
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Jha, V.K]]
+__TOC__
-[[Category: Ling, H]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Unidentified]]
+[[Category: Jha VK]]
+[[Category: Ling H]]