5t0h: Difference between revisions
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The | ==Structural basis for dynamic regulation of the human 26S proteasome== | ||
<SX load='5t0h' size='340' side='right' viewer='molstar' caption='[[5t0h]], [[Resolution|resolution]] 6.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5t0h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T0H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t0h OCA], [https://pdbe.org/5t0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t0h RCSB], [https://www.ebi.ac.uk/pdbsum/5t0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t0h ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PRS7_HUMAN PRS7_HUMAN] The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.<ref>PMID:9295362</ref> | |||
==See Also== | |||
*[[Proteasome 3D structures|Proteasome 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </SX> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Chen S]] | ||
[[Category: Ma | [[Category: Finley D]] | ||
[[Category: | [[Category: Kirschner MW]] | ||
[[Category: | [[Category: Lee BH]] | ||
[[Category: Wu | [[Category: Lu Y]] | ||
[[Category: | [[Category: Ma YB]] | ||
[[Category: Mao Y]] | |||
[[Category: Ouyang Q]] | |||
[[Category: Wu J]] | |||
[[Category: Yu Z]] | |||
Latest revision as of 18:34, 6 March 2024
Structural basis for dynamic regulation of the human 26S proteasomeStructural basis for dynamic regulation of the human 26S proteasome
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