5fbw: Difference between revisions

Latest revision as of 09:45, 19 July 2023

PI4KB in complex with Rab11 and the MI369 InhibitorPI4KB in complex with Rab11 and the MI369 Inhibitor

Structural highlights

5fbw is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.487Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PI4KB_HUMAN Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).^[1] ^[2] ^[3]

References

↑ Suzuki K, Hirano H, Okutomi K, Suzuki M, Kuga Y, Fujiwara T, Kanemoto N, Isono K, Horie M. Identification and characterization of a novel human phosphatidylinositol 4-kinase. DNA Res. 1997 Aug 31;4(4):273-80. PMID:9405935
↑ Godi A, Pertile P, Meyers R, Marra P, Di Tullio G, Iurisci C, Luini A, Corda D, De Matteis MA. ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex. Nat Cell Biol. 1999 Sep;1(5):280-7. PMID:10559940 doi:http://dx.doi.org/10.1038/12993
↑ Heilmeyer LM Jr, Vereb G Jr, Vereb G, Kakuk A, Szivak I. Mammalian phosphatidylinositol 4-kinases. IUBMB Life. 2003 Feb;55(2):59-65. PMID:12749687 doi:http://dx.doi.org/10.1002/tbmb.718540873

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OCA

[1] Suzuki K, Hirano H, Okutomi K, Suzuki M, Kuga Y, Fujiwara T, Kanemoto N, Isono K, Horie M. Identification and characterization of a novel human phosphatidylinositol 4-kinase. DNA Res. 1997 Aug 31;4(4):273-80. PMID:9405935

[2] Godi A, Pertile P, Meyers R, Marra P, Di Tullio G, Iurisci C, Luini A, Corda D, De Matteis MA. ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex. Nat Cell Biol. 1999 Sep;1(5):280-7. PMID:10559940 doi:http://dx.doi.org/10.1038/12993

[3] Heilmeyer LM Jr, Vereb G Jr, Vereb G, Kakuk A, Szivak I. Mammalian phosphatidylinositol 4-kinases. IUBMB Life. 2003 Feb;55(2):59-65. PMID:12749687 doi:http://dx.doi.org/10.1002/tbmb.718540873

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fbw is ON HOLD
+==PI4KB in complex with Rab11 and the MI369 Inhibitor==
+<StructureSection load='5fbw' size='340' side='right'caption='[[5fbw]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fbw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FBW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.487&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W8:~{N}-[2-[[6-CHLORANYL-3-[4-METHOXY-3-[[(2~{R})-1-OXIDANYLBUTAN-2-YL]SULFAMOYL]PHENYL]-2-METHYL-IMIDAZO[1,2-B]PYRIDAZIN-8-YL]AMINO]ETHYL]ETHANAMIDE'>5W8</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbw OCA], [https://pdbe.org/5fbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fbw RCSB], [https://www.ebi.ac.uk/pdbsum/5fbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PI4KB_HUMAN PI4KB_HUMAN] Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).<ref>PMID:9405935</ref> <ref>PMID:10559940</ref> <ref>PMID:12749687</ref>
-Authors: Chalupska, D., Mejdrova, I., Nencka, R., Boura, E.
+==See Also==
+*[[Phosphatidylinositol 4-kinase|Phosphatidylinositol 4-kinase]]
-Description: PI4KB in complex with Rab11 and the MI369 Inhibitor
+*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
-[[Category: Unreleased Structures]]
+== References ==
-[[Category: Boura, E]]
+<references/>
-[[Category: Chalupska, D]]
+__TOC__
-[[Category: Mejdrova, I]]
+</StructureSection>
-[[Category: Nencka, R]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Boura E]]
+[[Category: Chalupska D]]
+[[Category: Mejdrova I]]
+[[Category: Nencka R]]

5fbw: Difference between revisions

Latest revision as of 09:45, 19 July 2023

PI4KB in complex with Rab11 and the MI369 InhibitorPI4KB in complex with Rab11 and the MI369 Inhibitor

Structural highlights

Function

See Also

References

Contents

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5fbw: Difference between revisions

Latest revision as of 09:45, 19 July 2023

PI4KB in complex with Rab11 and the MI369 InhibitorPI4KB in complex with Rab11 and the MI369 Inhibitor

Structural highlights

Function

See Also

References

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