5ff9: Difference between revisions

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OCA

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 ==Noroxomaritidine/Norcraugsodine Reductase in Complex with NADP+ and tyramine==
-<StructureSection load='5ff9' size='340' side='right' caption='[[5ff9]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
+<StructureSection load='5ff9' size='340' side='right'caption='[[5ff9]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5ff9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FF9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5ff9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Narcissus_pseudonarcissus Narcissus pseudonarcissus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FF9 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEF:4-(2-AMINOETHYL)PHENOL'>AEF</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.814&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5feu|5feu]], [[5fff|5fff]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEF:4-(2-AMINOETHYL)PHENOL'>AEF</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ff9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ff9 OCA], [http://pdbe.org/5ff9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ff9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ff9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ff9 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ff9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ff9 OCA], [https://pdbe.org/5ff9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ff9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ff9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ff9 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NR_NARPS NR_NARPS] In the Amaryllidaceae alkaloids biosynthesic pathway, catalyzes the conversion of noroxomaritidine to oxomaritidine, a precursor of haemanthamine- and crinamine-type alkaloids, promising anticancer agents (PubMed:27252378). Can also, to some extent, catalyze the condensation of 3,4-dihydroxybenzaldehyde (3,4-DHBA) and tyramine to produce norbelladine, and of isovanillin and tyramine to produce 4'-O-methylnorbelladine (PubMed:27252378).<ref>PMID:27252378</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 23: @@
 __TOC__
 </StructureSection>
-[[Category: Holland, C K]]
+[[Category: Large Structures]]
-[[Category: Jez, J M]]
+[[Category: Narcissus pseudonarcissus]]
-[[Category: Oxidoreductase]]
+[[Category: Holland CK]]
-[[Category: Short-chain dehydrogenase/reductase alkaloid biosynthesis]]
+[[Category: Jez JM]]