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==Crystal structure of Trypanothione Reductase from Trypanosoma cruzi in complex with inhibitor EP127 (5-{5-[1-(PYRROLIDIN-1-YL)CYCLOHEXYL]-1,3-THIAZOL-2-YL}-1H-INDOLE)==
==Crystal structure of Trypanothione Reductase from Trypanosoma cruzi in complex with inhibitor EP127 (5-{5-[1-(PYRROLIDIN-1-YL)CYCLOHEXYL]-1,3-THIAZOL-2-YL}-1H-INDOLE)==
<StructureSection load='4new' size='340' side='right' caption='[[4new]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4new' size='340' side='right'caption='[[4new]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4new]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NEW FirstGlance]. <br>
<table><tr><td colspan='2'>[[4new]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NEW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2JR:5-{5-[1-(PYRROLIDIN-1-YL)CYCLOHEXYL]-1,3-THIAZOL-2-YL}-1H-INDOLE'>2JR</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nev|4nev]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2JR:5-{5-[1-(PYRROLIDIN-1-YL)CYCLOHEXYL]-1,3-THIAZOL-2-YL}-1H-INDOLE'>2JR</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4new FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4new OCA], [http://pdbe.org/4new PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4new RCSB], [http://www.ebi.ac.uk/pdbsum/4new PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4new ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4new FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4new OCA], [https://pdbe.org/4new PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4new RCSB], [https://www.ebi.ac.uk/pdbsum/4new PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4new ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</div>
</div>
<div class="pdbe-citations 4new" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4new" style="background-color:#fffaf0;"></div>
==See Also==
*[[Trypanothione reductase|Trypanothione reductase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bryson, S]]
[[Category: Large Structures]]
[[Category: Diederich, F]]
[[Category: Trypanosoma cruzi]]
[[Category: Krauth-Siegel, R L]]
[[Category: Bryson S]]
[[Category: Pai, E F]]
[[Category: Diederich F]]
[[Category: Persch, E]]
[[Category: Krauth-Siegel RL]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Pai EF]]
[[Category: Reductase]]
[[Category: Persch E]]

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