3dz2: Difference between revisions

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==Human AdoMetDC with 5'-[(3-aminopropyl)methylamino]-5'deoxy-8-methyladenosine==
==Human AdoMetDC with 5'-[(3-aminopropyl)methylamino]-5'deoxy-8-methyladenosine==
<StructureSection load='3dz2' size='340' side='right' caption='[[3dz2]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
<StructureSection load='3dz2' size='340' side='right'caption='[[3dz2]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3dz2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DZ2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3dz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DZ2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8M:5-[(3-AMINOPROPYL)(METHYL)AMINO]-5-DEOXY-8-METHYLADENOSINE'>A8M</scene>, <scene name='pdbligand=PUT:1,4-DIAMINOBUTANE'>PUT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8M:5-[(3-AMINOPROPYL)(METHYL)AMINO]-5-DEOXY-8-METHYLADENOSINE'>A8M</scene>, <scene name='pdbligand=PUT:1,4-DIAMINOBUTANE'>PUT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jen|1jen]], [[1i72|1i72]], [[1i7b|1i7b]], [[1i7c|1i7c]], [[1i79|1i79]], [[1i7m|1i7m]], [[3dz3|3dz3]], [[3dz4|3dz4]], [[3dz5|3dz5]], [[3dz6|3dz6]], [[3dz7|3dz7]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dz2 OCA], [https://pdbe.org/3dz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3dz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dz2 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AMD1, AMD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine_decarboxylase Adenosylmethionine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.50 4.1.1.50] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dz2 OCA], [http://pdbe.org/3dz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dz2 RCSB], [http://www.ebi.ac.uk/pdbsum/3dz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dz2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCAM_HUMAN DCAM_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/3dz2_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/3dz2_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adenosylmethionine decarboxylase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Bale, S]]
[[Category: Bale S]]
[[Category: Ealick, S E]]
[[Category: Ealick SE]]
[[Category: Guida, W C]]
[[Category: Guida WC]]
[[Category: III, J A.Secrist]]
[[Category: McCloskey DE]]
[[Category: McCloskey, D E]]
[[Category: Pegg AE]]
[[Category: Pegg, A E]]
[[Category: Secrist III JA]]
[[Category: Complexes of adometdc with 8-substituted ligand]]
[[Category: Decarboxylase]]
[[Category: Lyase]]
[[Category: Pyruvate]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Spermidine biosynthesis]]
[[Category: Zymogen]]

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