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==Crystal Structure of VldE, the pseudo-glycosyltransferase which catalyzes non-glycosidic C-N coupling in Validamycin A biosynthesis==
==Crystal Structure of VldE, the pseudo-glycosyltransferase which catalyzes non-glycosidic C-N coupling in Validamycin A biosynthesis==
<StructureSection load='3vdm' size='340' side='right' caption='[[3vdm]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
<StructureSection load='3vdm' size='340' side='right'caption='[[3vdm]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vdm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_hygroscopicus_subsp._limoneus"_shibata_et_al._1973 "streptomyces hygroscopicus subsp. limoneus" shibata et al. 1973]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VDM FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vdm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_hygroscopicus_subsp._limoneus Streptomyces hygroscopicus subsp. limoneus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VDM FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vdn|3vdn]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vldE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264445 "Streptomyces hygroscopicus subsp. limoneus" Shibata et al. 1973])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdm OCA], [https://pdbe.org/3vdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vdm RCSB], [https://www.ebi.ac.uk/pdbsum/3vdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vdm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdm OCA], [http://pdbe.org/3vdm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vdm RCSB], [http://www.ebi.ac.uk/pdbsum/3vdm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vdm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VLDE_STRHL VLDE_STRHL] Involved in the biosynthesis of the antifungal agent validamycin A (PubMed:16725283). Catalyzes the condensation between GDP-valienol and validamine 7-phosphate via a nonglycosidic C-N bond formation to yield validoxylamine A 7'-phosphate (PubMed:21766819).<ref>PMID:16725283</ref> <ref>PMID:21766819</ref>
==See Also==
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptomyces hygroscopicus subsp. limoneus shibata et al. 1973]]
[[Category: Large Structures]]
[[Category: Asamizu, S]]
[[Category: Streptomyces hygroscopicus subsp. limoneus]]
[[Category: Cavalier, M C]]
[[Category: Asamizu S]]
[[Category: Lee, Y H]]
[[Category: Cavalier MC]]
[[Category: Mahmud, T]]
[[Category: Lee Y-H]]
[[Category: Neau, D]]
[[Category: Mahmud T]]
[[Category: Yim, Y S]]
[[Category: Neau D]]
[[Category: Rossmann fold]]
[[Category: Yim Y-S]]
[[Category: Transferase]]

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