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==Crystal structure of the human TFIIE complex== | |||
<StructureSection load='5gpy' size='340' side='right'caption='[[5gpy]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5gpy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GPY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gpy OCA], [https://pdbe.org/5gpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gpy RCSB], [https://www.ebi.ac.uk/pdbsum/5gpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gpy ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/T2EA_HUMAN T2EA_HUMAN] Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | |||
==See Also== | |||
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Kojima R]] | ||
[[Category: | [[Category: Miwa K]] | ||
[[Category: | [[Category: Mizuguchi M]] | ||
[[Category: | [[Category: Obita T]] | ||
[[Category: Ohkuma Y]] | |||
[[Category: Tamura Y]] | |||
Latest revision as of 12:13, 20 March 2024
Crystal structure of the human TFIIE complexCrystal structure of the human TFIIE complex
Structural highlights
FunctionT2EA_HUMAN Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. See Also |
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