4mz3: Difference between revisions
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==Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain, C131W mutant== | ==Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain, C131W mutant== | ||
<StructureSection load='4mz3' size='340' side='right' caption='[[4mz3]], [[Resolution|resolution]] 1.74Å' scene=''> | <StructureSection load='4mz3' size='340' side='right'caption='[[4mz3]], [[Resolution|resolution]] 1.74Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mz3]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4mz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MZ3 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.741Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mz3 OCA], [https://pdbe.org/4mz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mz3 RCSB], [https://www.ebi.ac.uk/pdbsum/4mz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mz3 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN] Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN] Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Ion channels|Ion channels]] | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Das S]] | ||
[[Category: | [[Category: Van Petegem F]] | ||