4mdt: Difference between revisions

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==Structure of LpxC bound to the reaction product UDP-(3-O-(R-3-hydroxymyristoyl))-glucosamine==
==Structure of LpxC bound to the reaction product UDP-(3-O-(R-3-hydroxymyristoyl))-glucosamine==
<StructureSection load='4mdt' size='340' side='right' caption='[[4mdt]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
<StructureSection load='4mdt' size='340' side='right'caption='[[4mdt]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MDT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mdt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MDT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=24G:URIDINE-5-DIPHOSPHATE-3-O-(R-3-HYDROXYMYRISTOYL)-GLUCOSAMINE'>24G</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxC, O3O_04310 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=24G:URIDINE-5-DIPHOSPHATE-3-O-(R-3-HYDROXYMYRISTOYL)-GLUCOSAMINE'>24G</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mdt OCA], [http://pdbe.org/4mdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mdt RCSB], [http://www.ebi.ac.uk/pdbsum/4mdt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mdt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mdt OCA], [https://pdbe.org/4mdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mdt RCSB], [https://www.ebi.ac.uk/pdbsum/4mdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mdt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/K0BGQ2_ECO1E K0BGQ2_ECO1E]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).[HAMAP-Rule:MF_00388][SAAS:SAAS015870_004_013136]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Clayton, G M]]
[[Category: Large Structures]]
[[Category: Klein, D J]]
[[Category: Clayton GM]]
[[Category: Kornienko, M]]
[[Category: Klein DJ]]
[[Category: Lumb, K J]]
[[Category: Kornienko M]]
[[Category: Miesel, L]]
[[Category: Lumb KJ]]
[[Category: Patel, S B]]
[[Category: Miesel L]]
[[Category: Reid, J C]]
[[Category: Patel SB]]
[[Category: Rickert, K W]]
[[Category: Reid JC]]
[[Category: Sharma, S]]
[[Category: Rickert KW]]
[[Category: Singh, S B]]
[[Category: Sharma S]]
[[Category: Soisson, S M]]
[[Category: Singh SB]]
[[Category: Tummala, S]]
[[Category: Soisson SM]]
[[Category: Zugay-Murphy, J]]
[[Category: Tummala S]]
[[Category: Deacetylase]]
[[Category: Zugay-Murphy J]]
[[Category: Hydrolase]]

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